3771-14-0

Basic information

• Product Name: 4-hydroxynaphthalene-2-sulphonic acid
• Synonyms: 4-hydroxynaphthalene-2-sulphonic acid;4-hydroxynaphthalene-2-sulfonic acid;4-Hydroxy-2-naphthalenesulfonic acid
• CAS NO: 3771-14-0
• Molecular Formula: C₁₀H₈O₄S
• Molecular Weight: 224.23312
• EINECS: 223-212-7
• Mol File: 3771-14-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.549g/cm³
• Refractive Index: 1.703
• PKA: 0.15±0.40(Predicted)
• CAS DataBase Reference: 4-hydroxynaphthalene-2-sulphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxynaphthalene-2-sulphonic acid(3771-14-0)
• EPA Substance Registry System: 4-hydroxynaphthalene-2-sulphonic acid(3771-14-0)

Safety Data

• Hazardous Substances Data: 3771-14-0(Hazardous Substances Data)

Usage

General Description

4-hydroxynaphthalene-2-sulphonic acid is a chemical compound with a molecular formula C10H8O4S. It is derived from naphthalene and contains a hydroxyl group and a sulfonic acid group. 4-hydroxynaphthalene-2-sulphonic acid is commonly used as an intermediate in the synthesis of dyes and pigments, as well as in the production of pharmaceuticals. It is also used as a pH indicator and as a fluorescent dye in biological and chemical research. 4-hydroxynaphthalene-2-sulphonic acid is a water-soluble compound and is commonly found in the form of a white to off-white powder. It is important to handle and store this compound with care, as it can be harmful if ingested or inhaled, and can cause irritation to the skin and eyes.

InChI:InChI=1/C10H8O4S/c11-10-6-8(15(12,13)14)5-7-3-1-2-4-9(7)10/h1-6,11H,(H,12,13,14)

Upstream product

• 64-17-5 ethanol 
• 34154-00-2 8-hydroxy-6-sulfo-naphthalene-2-diazonium-betaine 
• 90-51-7 6-amino-4-hydroxy-2-naphthalenesulfonic acid 
• 1542203-80-4 1-octanoyloxynaphthalene-3-sulfonic acid 
• 860363-74-2 6-hydrazino-4-hydroxy-naphthalene-2-sulfonic acid 
• 7758-99-8 copper(II) sulfate 
• 7732-18-5 water 
• 6094-26-4 naphthalene-1,3-disulfonic acid 
• 117-43-1 8-hydroxy-naphthalene-1,6-disulfonic acid 
• 134-54-3 4-aminonaphthalene-2-sulfonic acid 
• 15119-80-9 4-oxo-1,2,3,4-tetrahydro-naphthalene-2-sulfonic acid 
• 86-65-7 2-aminonaphthalene-6,8-disulfonate 

Downstream Products

• 109156-09-4 4-hydroxy-3-(4-nitro-phenylazo)-naphthalene-2-sulfonic acid 
• 25107-88-4 4-hydroxy-1-(4-nitro-phenylazo)-naphthalene-2-sulfonic acid 
• 24824-28-0 naphthalene-1,3-diamine 
• 1254103-31-5 C₃₁H₂₆N₂O₅S 
• 1254576-59-4 C₄₈H₃₈N₄O₁₁S₂ 
• 109156-08-3 4-hydroxy-3-(2-nitro-phenylazo)-naphthalene-2-sulfonic acid 
• 109156-10-7 4-hydroxy-1-(2-nitro-phenylazo)-naphthalene-2-sulfonic acid 
• 4531-72-0 3-(4-chloro-phenylazo)-4-hydroxy-naphthalene-2-sulfonic acid 
• 1215771-99-5 C₄₁H₃₂N₄O₈S₂ 
• 118-90-1 ortho-methylbenzoic acid 

Relevant articles and documents

A chromogenic substrate for solid-phase detection of phospholipase A 2

A method for solid-phase detection of phospholipase A2 (PLA 2) was developed. The method uses 1-octanoyloxynaphthalene-3-sulfonic acid, which was found to be a good substrate of PLA2. The substrate is hydrolyzed by PLA2 into 1-naphthol-3-sulfonic acid, which is spontaneously coupled with coexisting diazonium salt to form a red-purple azo dye. Streptomyces and bovine pancreatic PLA2 spotted on a nitrocellulose membrane could be detected by this method with considerable sensitivity. In addition, colonies of recombinant Escherichia coli producing bacterial PLA2 were distinguishable from those producing an inactive mutant PLA2, facilitating high-throughput screening in directed evolution of the enzyme.