37884-02-9

Basic information

• Product Name: 6-chloro-2-methyl-9H-xanthen-9-one
• CAS NO: 37884-02-9
• Molecular Formula: C₁₄H₉ClO₂
• Molecular Weight: 244.6731
• Mol File: 37884-02-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 397.3°C at 760 mmHg
• Flash Point: 171.1°C
• Density: 1.345g/cm³
• Vapor Pressure: 1.6E-06mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 6-chloro-2-methyl-9H-xanthen-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-methyl-9H-xanthen-9-one(37884-02-9)
• EPA Substance Registry System: 6-chloro-2-methyl-9H-xanthen-9-one(37884-02-9)

Safety Data

• Hazardous Substances Data: 37884-02-9(Hazardous Substances Data)

Usage

Color

Fluorescent pink

Use

Dye in scientific studies, inks, paints, plastics; tracer in water and air flow studies

Chemical Class

Xanthenes

Health Hazards

Potential toxicity to aquatic organisms; harmful effects if ingested or inhaled in large amounts

Regulation

Banned in some countries due to health hazards and environmental toxicity

Upstream product

• 92153-14-5 2,4-dichloro-2'-hydroxy-5'-methyl-benzophenone 
• 13014-18-1 2,4-dichlorobenzotrichloride 
• 1121-70-6 sodium 4-methylphenoxide 
• 38402-11-8 2,4-dichlorobenzoic acid sodium salt 
• 108-43-0 3-monochlorophenol 
• 5858-28-6 5-methyl-2-nitrobenzaldehyde 
• 106-44-5 p-cresol 
• 50-84-0 2,4 dichlorobenzoic acid 
• 50970-69-9 2-(p-methylphenyloxy)-4-chlorobenzoic acid 

Downstream Products

• 1446787-24-1 6-methoxy-2-{[4-(benzyl)piperazin-1-yl]methyl}-9H-xanthen-9-one 
• 1446787-25-2 6-methoxy-2-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-9H-xanthen-9-one 
• 1446787-32-1 6-methoxy-2-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-9H-xanthen-9-one hydrochloride 

Relevant articles and documents

Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis

Transthyretin is a tetrameric protein which functions as a transporter of thyroxine and retinol-binding protein. Misfolding and amyloid aggregation of transthyretin are known to cause wild-type and hereditary transthyretin amyloidosis. Stabilization of the transthyretin tetramer by low molecular weight compounds is an efficacious strategy to inhibit the aggregation pathway in the amyloidosis. Here, we investigated the inhibitory activities of anthraquinone and xanthone derivatives against amyloid aggregation, and found that xanthone-2-carboxylic acid with one chlorine or methyl group has strong inhibitory activity comparable with that of diflunisal, which is one of the best known stabilizers of transthyretin. X-ray crystallographic structures of transthyretin in complex with the compounds revealed that the introduction of chlorine, which is buried in a hydrophobic region, is important for the strong inhibitory effect of the stabilizer against amyloidogenesis. An in vitro absorption, distribution, metabolism and elimination (ADME) study and in vivo pharmacokinetic study demonstrated that the compounds have drug-like features, suggesting that they have potential as therapeutic agents to stabilize transthyretin.

XANTHONE DERIVATIVES, UV PROTECTIVE COMPOSITION CONCENTRATE, METHOD OF PREPARATION OF UV PROTECTIVE COMPOSITION CONCENTRATE, USE OF UV PROTECTIVE COMPOSITION CONCENTRATE AND COSMETIC UV PROTECTIVE PRODUCT

The first object of the invention is a xanthone derivative described by formula (I) where R1 is a substituent selected from the group comprising: hydrogen or alkoxy group; R2 is a substituent selected from the group comprising methyl

Anticonvulsant evaluation of aminoalkanol derivatives of 2- and 4-methylxanthone

A series of 17 new aminoalkanol derivatives of 6-methoxy- or 7-chloro-2-methylxanthone as well as 6-methoxy-4-methylxanthone was synthesized and evaluated for anticonvulsant activity. All compounds were verified in mice after intraperitoneal (ip) administ