3792-04-9

Basic information

• Product Name: N-(CHLOROACETYL)-2-(TRIFLUOROMETHYL)ANILINE
• Synonyms: N-Chloroacetyl-2-(trifluoromethyl)aniline97%;FLC N-(Chloroacetyl)-2-(trifluoromethyl)aniline;2-chloro-N-[2-(trifluoromethyl)phenyl]acetamide(SALTDATA: FREE);2-chloro-N-[2-(trifluoromethyl)phenyl]ethanamide;2-CHLORO-N-[2-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE;2-CHLORO-2'-(TRIFLUOROMETHYL)ACETANILIDE;AKOS B015649;ACETAMIDE, 2-CHLORO-N-[2-(TRIFLUOROMETHYL)PHENYL]-
• CAS NO: 3792-04-9
• Molecular Formula: C₉H₇ClF₃NO
• Molecular Weight: 237.61
• Mol File: 3792-04-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 92-94°C
• Boiling Point: 205°Cat760mmHg
• Flash Point: 85°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 0.000159mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 12.13±0.70(Predicted)
• CAS DataBase Reference: N-(CHLOROACETYL)-2-(TRIFLUOROMETHYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(CHLOROACETYL)-2-(TRIFLUOROMETHYL)ANILINE(3792-04-9)
• EPA Substance Registry System: N-(CHLOROACETYL)-2-(TRIFLUOROMETHYL)ANILINE(3792-04-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 3792-04-9(Hazardous Substances Data)

Usage

General Description

N-(chloroacetyl)-2-(trifluoromethyl)aniline is a chemical compound used in the synthesis of pharmaceuticals and agrochemicals. It is an aromatic amine with a trifluoromethyl group and a chloroacetyl group attached to the nitrogen atom. N-(CHLOROACETYL)-2-(TRIFLUOROMETHYL)ANILINE is often used as a building block in the production of various chemicals and pharmaceuticals, and it is known for its potential as an intermediate in organic synthesis. N-(chloroacetyl)-2-(trifluoromethyl)aniline is a highly reactive compound and should be handled with care, as it can pose health and environmental risks if not properly managed.

InChI:InChI=1/C9H7ClF3NO/c10-5-8(15)14-7-4-2-1-3-6(7)9(11,12)13/h1-4H,5H2,(H,14,15)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 88-17-5 2-(trifluoromethyl)benzenamine 

Downstream Products

• 937704-78-4 C₂₂H₂₃N₂O₅F₃ 
• 444-93-9 (E)-2-(hydroxyimino)-N-(2-(trifluoromethyl)phenyl)acetamide 

Relevant articles and documents

Design, Synthesis, Antibacterial Activity, and Mechanisms of Novel 1,3,4-Thiadiazole Derivatives Containing an Amide Moiety

To discover novel antibacterial agents, a series of novel 1,3,4-thiadiazole derivatives containing an amide moiety were designed and synthesized, and their antibacterial activities were tested. Compound 30 was designed and synthesized according to the CoMFA model. Compound 30 exhibited higher antibacterial activities against Xanthomonas oryzae pv. oryzicola and Xanthomonas oryzae pv. oryzae, with EC50 values of 2.1 and 1.8 mg/L, respectively, which were superior to those of thiodiazole copper (99.6 and 92.5 mg/L). The protective and curative activities of compound 30 against rice bacterial leaf blight were 51.3 and 46.1%, respectively, which were better than those of thiodiazole copper (37.8 and 38.5%). The protective and curative activities of compound 30 against rice bacterial leaf streak were 45.9 and 40.5%, respectively, which were better than those of thiodiazole copper (36.2 and 31.1%). In addition, the protective activity of compound 30 against rice bacterial leaf streak was related to increased activities of related defense enzymes and upregulated the differentially expressed proteins of the glycolysis/gluconeogenesis pathway.

Antidiabetic compounds

Compounds for the treatment of hyperglycemia and/or diabetes are provided. The compounds, which inhibit the enzyme dipeptidyl peptidase (DPP-4), are based on the structure where X may be present or absent an may be OH, Ar is an aryl group; and n ranges from 0 to 5.

Synthesis and biological evaluation of N-(substituted phenyl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamides as antimicrobial, antidepressant, and anticonvulsant agents

A new series of N-Aryl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamides were synthesized by condensation of tricyclic compound 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione with chloro N-phenylacetamides. The tricyclic compound was obtaine