380-69-8

Basic information

• Product Name: Propanedioic acid, (acetylamino)[(2-fluorophenyl)methyl]-, diethyl ester
• CAS NO: 380-69-8
• Molecular Formula: C16H20FNO5
• Molecular Weight: 325.337
• Mol File: 380-69-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (acetylamino)[(2-fluorophenyl)methyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (acetylamino)[(2-fluorophenyl)methyl]-, diethyl ester(380-69-8)
• EPA Substance Registry System: Propanedioic acid, (acetylamino)[(2-fluorophenyl)methyl]-, diethyl ester(380-69-8)

Safety Data

• Hazardous Substances Data: 380-69-8(Hazardous Substances Data)

Upstream product

• 13433-00-6 diethyl aminomalonate hydrochloride 
• 446-48-0 o-fluorobenzyl bromide 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 345-35-7 2-fluorobenzyl chloride 

Downstream Products

• 97731-02-7 (R)-2'-fluorophenylalanine 
• 453-98-5 N-acetyl-2-fluoro-L-phenylalanine-(N'-phenyl-hydrazide) 
• 69126-95-0 N-acetyl-2-fluoro-D-phenylalanine 
• 2629-55-2 2-fluoro-DL-phenylalanine 
• 66574-84-3 N-acetyl-2-fluoro-DL-phenylalanine 

Relevant articles and documents

Organocatalytic Enantioselective Addition of α-Aminoalkyl Radicals to Isoquinolines

With a dual organocatalytic system involving a chiral phosphoric acid and a dicyanopyrazine-derived chromophore (DPZ) photosensitizer and under the irradiation with visible light, an enantioselective Minisci-type addition of α-amino acid-derived redox-active esters (RAEs) to isoquinolines has been developed. A variety of prochiral α-aminoalkyl radicals generated from RAEs were successfully introduced on isoquinolines, providing a range of valuable α-isoquinoline-substituted chiral secondary amines in high yields with good to excellent enantioselectivities.