38041-19-9

Basic information

• Product Name: 4-Aminotetrahydropyran
• Synonyms: 2H-PYRAN-4-AMINE, TETRAHYDRO-;4-AMINOTETRAHYDROPYRAN;TETRAHYDRO-PYRAN-4-YLAMINE;TETRAHYDRO-2H-PYRAN-4-AMINE;TETRAHYDRO-2H-PYRAN-4-YLAMINE;4-Aminotetrahydro-2H-pyran;4-AMINOTETRAHYDROPYRAN 4-AMINOTETRAHYDRO-2H-PYRAN;2H-Pyran-4-amine,tetrahydro-(9CI)
• CAS NO: 38041-19-9
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Product Categories: VARIOUSAMINE;Amines;blocks;Heterocycles;Amines and Anilines;pharmacetical;Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Pyrans
• Mol File: 38041-19-9.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 60 °C
• Flash Point: 54°C
• Appearance: /
• Density: 0.977g/cm3at 25℃
• Vapor Pressure: 3.68mmHg at 25°C
• Refractive Index: n20/D 1.463
• Storage Temp.: Store under Argon or Nitrogen
• PKA: 9.63±0.20(Predicted)
• CAS DataBase Reference: 4-Aminotetrahydropyran(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Aminotetrahydropyran(38041-19-9)
• EPA Substance Registry System: 4-Aminotetrahydropyran(38041-19-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 10-34-41-22-37/18
• Safety Statements: 16-26-36/37/39-39
• RIDADR: 2734
• WGK Germany: 1
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 38041-19-9(Hazardous Substances Data)

Usage

Description

4-Aminotetrahydropyran is a chemical compound that features a tetrahydropyran ring, which is a common three-dimensional ring system found in many marketed drugs. 4-Aminotetrahydropyran is particularly notable for its utility in the synthesis of aminothiazole compounds, which have potential applications in the treatment of cancer. The tetrahydropyran ring's prevalence in pharmaceuticals and its role in drug discovery make 4-Aminotetrahydropyran a valuable component in the development of cancer treatments.

Uses

Used in Pharmaceutical Industry:
4-Aminotetrahydropyran is used as a reactant/reagent for the synthesis of aminothiazole compounds, which are crucial in the development of cancer treatments. Its tetrahydropyran ring structure contributes to the effectiveness of these compounds, making it an essential component in the fight against cancer.
Used in Drug Discovery:
The scaffold of 4-Aminotetrahydropyran is highly useful in drug discovery, particularly for cancer treatment. Its presence in many marketed drugs highlights the importance of this compound in the ongoing research and development of novel therapeutics to combat various types of cancer.

InChI:InChI=1/C5H11NO/c6-5-1-3-7-4-2-5/h5H,1-4,6H2/p+1

Upstream product

• 61128-73-2 tetrahydropyran-4-one oxime 
• 1080028-76-7 C₁₀H₁₉NO₂ 
• 2081-44-9 Tetrahydro-pyran-4-ol 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 116312-69-7 tetrahydro-2H-pyran-4-yl-hydrazine 
• 625126-73-0 N-(Diphenylmethyl)tetrahydro-2H-pyran-4-amine 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 60-29-7 diethyl ether 
• 344329-76-6 tetrahydro-pyran-4-carboxylic acid amide 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 

Downstream Products

• 676628-27-6 6-(3-chloro-phenylamino)-4-isopropyl-N-(tetrahydro-pyran-4-yl)-nicotinamide 
• 320406-32-4 1-(tetrahydropyran-4-yl)amino-2-nitro-4-trifluoromethylbenzene 
• 1256969-14-8 2-(4-chloro-2-((tetrahydropyran-4-yl)amino)nitrobenzen-5-yl)benzoxazole 
• 449809-40-9 8-Amino-6-(2,4-difluoro-phenoxy)-2-(tetrahydro-pyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 875151-73-8 (S)-2-(BOC-amino)-3-(4-hydroxy-phenyl)-2-methyl-N-(tetrahydro-pyran-4-yl)-propionamide 
• 874888-73-0 C₁₈H₂₈N₂O₃ 
• 893420-31-0 4-iodo-N-(tetrahydro-2H-pyran-4-yl)benzamide 
• 33024-60-1 tetrahydro-2H-pyran-4-ylamine monohydrochloride 
• 856696-06-5 1,1-dimethylethyl [(1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(tetrahydro-2H-pyran-4-ylamino)propyl]-carbamate 
• 691863-98-6 2-methyl-4-(2-chlorophenyl)-6-(tetrahydropyranyl-4-amino)-4H-1,3,4-pyrimido[4,5-e]oxadiazine 

Relevant articles and documents

Preparation method of important intermediate 4-aminotetrahydropyran

The invention discloses a preparation method of an important intermediate 4-aminotetrahydropyran. The method comprises the following steps that tetrahydro-4-pyranol is dissolved in polyethylene glycol-200, a prepared Cu-Mo/TS-1 composite is added, a mixture is heated to 60-80 DEG C, under a stirring condition, ammonium hydroxide is added into the mixture dropwise, after dropping is completed, heat-preservation stirring reaction is carried out for 5-6 h, and filtering, extraction and recrystallization are conducted to prepare the 4-aminotetrahydropyran. The preparation method is simple to operate, conditions are mild, by-products are few, the product purity is high, and the product yield is high.

Heterogeneous Catalytic Reductive Amination of Carbonyl Compounds with Ni-Al Alloy in Water as Solvent and Hydrogen Source

The heterogeneous catalytic reductive amination of carbonyl compounds has been achieved by reactions of ammonium hydroxide and various amines with ketones and aldehydes. The process is based on the application of Raney type Ni-Al alloy in an aqueous medium. The reaction of the carbonyl compounds with the amine provided the corresponding Schiff bases that immediately underwent a reduction to provide primary and secondary amines as products. The controlled reaction of the Al content of the alloy with the solvent water generates hydrogen, and the in situ formed Raney Ni serves as a hydrogenation catalyst. The method is a simple and efficient way of preparing a broad variety of primary and secondary amines.

IMIDAZO [1, 2 - B] PYRIDAZINE - BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF

Imidazo[1,2-b]pyridazine-based compounds of the formula (I): are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.