38049-01-3

Basic information

• Product Name: 2-<(1S,2R,4R)-2-hydroxy-4-methylcyclohexyl>-2-propenal
• Synonyms: 2-<(1S,2R,4R)-2-hydroxy-4-methylcyclohexyl>-2-propenal
• CAS NO: 38049-01-3
• Molecular Weight: 168.236
• Mol File: 38049-01-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-<(1S,2R,4R)-2-hydroxy-4-methylcyclohexyl>-2-propenal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<(1S,2R,4R)-2-hydroxy-4-methylcyclohexyl>-2-propenal(38049-01-3)
• EPA Substance Registry System: 2-<(1S,2R,4R)-2-hydroxy-4-methylcyclohexyl>-2-propenal(38049-01-3)

Safety Data

• Hazardous Substances Data: 38049-01-3(Hazardous Substances Data)

Upstream product

• 13834-14-5 (+/-)-(1RS,3SR,4SR)-p-menth-8⁽¹⁰⁾-ene-ane-3,9-diol 
• 106-23-0 3,7-dimethyl-oct-6-enal 
• 89-79-2 (rac)-neo-isopulegol 
• 29606-79-9 p-menth-8-en-3-one 
• 13834-13-4 (1S,2R,5R)-5-Methyl-2-((S)-2-methyl-oxiranyl)-cyclohexanol 
• 89-79-2 isopulegol 
• 89-49-6 epiisopulegol acetate 
• 13834-14-5 (+/-)-(1RS,3SR,4SR)-p-menth-8⁽¹⁰⁾-ene-3,9-diol 
• 89-49-6 Acetic acid (1R,2S,5R)-2-isopropenyl-5-methyl-cyclohexyl ester 
• 13834-14-5 2-<(1S,2R,4R)-2-hydroxy-4-methylcyclohexyl>-2-propen-1-ol 
• 89-79-2 isopulegol 
• 7786-67-6 isopulegol 
• 57576-09-7 (1R,2S,5R)-5-methyl-2-(prop-1-en-2-yl)cyclohexyl acetate 
• 38048-99-6 acetoxy-3 p-menthene-8 ⁽¹⁰⁾ al-9 

Relevant articles and documents

Enzyme-mediated preparation of enantiomerically pure p-menthan-3,9-diols and their use for the synthesis of natural p-menthane lactones and ethers

The diastereoselective preparation of the p-menthane-3,9-diols (±)-12, (±)-13a, (±)-13b, and (±)-18 and the study of their enzymic resolution is described (Scheme 1). The corresponding enantiomer-enriched diols obtained by means of the lipase-mediated kinetic acetylation of the racemic diols are suitable synthetic precursors of many relevant p-menthane monoterpenes. Their usefulness is shown in the preparation of different natural products of this class that are interesting for industrial purposes because of their odor qualities, i.e., of the enantiomeric form of 3-hydroxy-p-menthan-9-oic acid lactone 1, of mintlactone 2, of the 3,9-epoxy-p-menth-1,8(10)-diene 10, and of the pheromone vesperal 11 (Schemes 2 and 3).

TOTAL SYNTHESIS OF VARIOUS ELEMANOLIDES

Starting with a suitable substituted divinyl cyclohexanone, eleven naturally occurring 12.8-elemanolides bearing exo-methylene or methyl groups at C-11 and differing in substitution as well as in relative configuration, have been synthesized in racemic form.An approach to elemanolides with additional oxygen functionalities is principally possible by modification of the basic concept.Methods for the oxidative generation of terpenoid exo-methylene lactone and furan units are exemplified by synthesis of menthofuran and the p-menthenolides from isopulegols.