38064-90-3Relevant articles and documents
KRAS G12D INHIBITORS
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Paragraph 0361, (2021/03/05)
The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
A solvent-controlled highly efficient Pd-C catalyzed hydrogenolysis of benzaldehydes to methylbenzenes via a novel 'acetal pathway'
Xing, Lixin,Wang, Xinyan,Cheng, Chuanjie,Zhu, Rui,Liu, Bo,Hu, Yuefei
, p. 9382 - 9386 (2008/02/10)
Pd-C catalyzed hydrogenolysis of benzaldehydes to methylbenzenes has been described to proceed via a 'benzenemethanol pathway'. In this article, a novel 'acetal pathway' was first revealed by a systematic study when lower alcohols were used as solvents and a solvent-controlled highly efficient procedure was established.
The Synthesis of Mycophenolic Acid from 2,4-Dihydroxybenzoic Acid
Patterson, John W.
, p. 4542 - 4548 (2007/10/02)
Mycophenolic acid (1) has been synthesized from 2,4-dihydroxybenzoic acid by regioselective introduction of the three required carbon substituents.A key transformation in this sequence is the introduction of the methyl substituent at position 5 by a rapid, uncatalyzed replacement of the bromide in 8 at low temperature by methyllithium.The scope and mechanism of this methylation reaction are examined.