38150-01-5

Basic information

• Product Name: 2-nitrocyclohexane-1,3-diol
• CAS NO: 38150-01-5
• Molecular Formula: C₆H₁₁NO₄
• Molecular Weight: 161.1558
• Mol File: 38150-01-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 345°C at 760 mmHg
• Flash Point: 158.7°C
• Density: 1.35g/cm³
• Vapor Pressure: 4.02E-06mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 2-nitrocyclohexane-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitrocyclohexane-1,3-diol(38150-01-5)
• EPA Substance Registry System: 2-nitrocyclohexane-1,3-diol(38150-01-5)

Safety Data

• Hazardous Substances Data: 38150-01-5(Hazardous Substances Data)

Usage

General Description

2-nitrocyclohexane-1,3-diol is a chemical compound with the molecular formula C6H11NO4. It is a nitro compound, which means it contains a nitro group (NO2). 2-nitrocyclohexane-1,3-diol is a diol, meaning it has two hydroxyl groups (-OH) attached to a cyclohexane ring. It is used in organic synthesis as a precursor for various other chemicals, and it has potential applications in pharmaceutical and industrial processes. However, it is also considered a hazardous compound and should be handled with care due to its potential toxicity and environmental impact.

Upstream product

• 75-52-5 nitromethane 
• 111-30-8 Glutaraldehyde 
• 625-48-9 2-nitro-1-ethanol 
• 51269-14-8 (1R,2r,3S)-3-acetoxy-2-nitrocyclohexyl acetate 

Downstream Products

• 18961-37-0 4,4'-(2-nitro-cyclohexane-1,3-diyl)-bis-morpholine 
• 51254-77-4 2-nitro-2-cyclohexene-1-ol 
• 38332-12-6 (1α,2β,3α)-2-amino-1,3-cyclohexanediol 
• 51269-14-8 (1R,2r,3S)-3-acetoxy-2-nitrocyclohexyl acetate 
• 38150-02-6 1,3-Di-O-methyl-2-t-nitrocyclohexan-1r,3c-diol 
• 23153-40-4 3-Benzylmercapto-2-nitrocyclohexen-⁽¹⁾ 
• 23153-82-4 1ref,3cis-Bis-benzylmercapto-2cis-nitro-cyclohexan 
• 19034-91-4 2t-Nitro-1r,3c-bis-cyclohexylamino-cyclohexan 
• 31285-24-2 1r,3c-Dimesyloxy-2t-nitrocyclohexan 
• 18961-33-6 2t-Nitro-1r,3c-bis-dimethylamino-cyclohexan 
• 19034-92-5 2t-Nitro-1r,3c-dianilino-cyclohexan 
• 16906-89-1 2trans-Nitro-1ref,3cis-bis--cyclohexan 
• 15910-77-7 (trans,trans)-N¹,N³-dibenzyl-2-nitrocyclohexane-1,3-diamine 
• 108267-19-2 <(S)-2-nitro-2-cyclohexenyl>-acetat 

Relevant articles and documents

HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS

Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

TRIAZOLE PYRIDYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.

Combination of cyclohexane and piperazine based κ-opioid receptor agonists: Synthesis and pharmacological evaluation of trans,trans-configured perhydroquinoxalines

Desymmetrization of the pseudochiral (2r)-configured cyclohexane-1,2,3- triamines 8 with dimethyl oxalate led to racemic aminoquinoxaline-2,3-diones 9. Selective introduction of the κ pharmacophoric structural elements pyrrolidine and 3,4-dichlorophenylacetamide with a two-carbon distance afforded conformationally restricted κ agonists 13-15 based on the quinoxaline ring system. In competitive radioligand receptor binding studies the benzylamine 13b, the secondary amine 14b, and the carbamate 15 displayed high κ receptor affinity. The Ki value of the lead compound derived methoxycarbonyl derivative 15 is 9.7 nM. However, the κ affinity of 15 is exceeded by 13b and 14b with a basic functional group instead of the methoxycarbonyl group in 1-position of the quinoxaline system. The chlorine atoms of the dichlorophenylacetyl residue are essential, since the corresponding phenylacetyl analogs show considerably reduced κ affinity. The potent κ ligands 13b, 14b and 15 are selective over the related μ- and δ-opioid receptors, σ1, σ2 and NMDA receptors. In the [35S]GTPγS-binding assay 13b behaved as partial agonist with lower activity than U-69,593.