38260-01-4 Usage
Description
Triethylenetetramine dihydrochloride, also known as trientine hydrochloride, is a white crystalline powder that functions as a selective CuII-chelator and a crosslinking agent. It is primarily used in the pharmaceutical industry for the treatment of Wilson's Disease, particularly in patients who are intolerant of penicillamine therapy. Additionally, it is undergoing trials for the treatment of heart failure in patients with diabetes.
Uses
Used in Pharmaceutical Industry:
Triethylenetetramine dihydrochloride is used as an oral medication for the treatment of Wilson's Disease, an inherited defect in copper metabolism. It is particularly effective for patients who are intolerant of penicillamine therapy.
Used in Antimicrobial Applications:
Triethylenetetramine dihydrochloride is used as an antibacterial agent, providing a means to combat bacterial infections.
Used in Chemical Industry:
Triethylenetetramine dihydrochloride is used as a crosslinking agent and a thermosetting resin, contributing to the production of various industrial materials.
Used as Epoxy Curing Agent:
In the manufacturing of epoxy resins, triethylenetetramine dihydrochloride is used as a curing agent, which helps in hardening the resin and providing structural integrity to the final product.
Used as Lubricating Oil Additive:
Triethylenetetramine dihydrochloride is used as an additive in the lubricating oil industry to enhance the performance and longevity of the oil.
Used as Analytical Reagent:
It is employed as an analytical reagent for the detection and measurement of copper (Cu) and nickel (Ni) in various samples.
Brand Names:
Triethylenetetramine dihydrochloride is commercially available under the brand names Syprine (Merck) and Cuprid.
Originator
Cambridge University (United Kingdom)
Check Digit Verification of cas no
The CAS Registry Mumber 38260-01-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,2,6 and 0 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 38260-01:
(7*3)+(6*8)+(5*2)+(4*6)+(3*0)+(2*0)+(1*1)=104
104 % 10 = 4
So 38260-01-4 is a valid CAS Registry Number.
38260-01-4Relevant articles and documents
PROCESS FOR PREPARING TRIENTINE DIHYDROCHLORIDE
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Page/Page column 13-14, (2021/10/02)
The present invention relates to a process for preparing trientine dihydrochloride as an active pharmaceutical ingredient (API). The present invention relates to a process for the preparation of trientine dihydrochloride with a pharmaceutical grade of purity. The invention also relates to novel intermediates used in the preparation of trientine dihydrochloride.
IMPROVED METHOD FOR THE SYNTHESIS OF 1,2-ETHANEDIAMINE, N, N'-BIS(2-AMINOETHYL)-DIHYDROCHLORIDE(TRIENTINE DIHYDROCHLORIDE)
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Page/Page column 18; 20; 21, (2018/11/22)
The present invention relates to an improved method for the synthesis of substantially pure 1,2-ethanediamine, N, N'-bis(2-aminoethyl)-dihydrochloride (I). Formula (I). Ν,Ν'-bis (2-aminoethyl)-l,2-ethanediamine dihydrochloride (Trientine dihydrochloride)
AN IMPROVED PROCESS FOR PREPARATION OF TRIENTINE DIHYDROCHLORIDE
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Page/Page column 8, (2017/04/11)
The present invention provides a process for preparation of trientine dihydrochloride (1) comprising reaction of protected triethylene tetramine with hydrochloric acid in an aqueous system to yield the dihydrochloride salt wherein the formation of inorganic impurities and undesired salts is controlled significantly.
