383418-30-2Relevant articles and documents
A straightforward synthesis of the CERT inhibitor (1′R,3′S)-HPA-12
Abad, José-Luis,Armero, Iván,Delgado, Antonio
, p. 1706 - 1708 (2015)
A straightforward synthesis of the CERT inhibitor HPA-12, (1′R,3′S)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide, is reported. The method requires only five synthetic steps from commercially available d-aspartic acid and leads to enantiopure HPA-12 in good overall yields.
A chemoenzymatic synthesis of ceramide trafficking inhibitor HPA-12
Kanojia, Seema V.,Chatterjee, Sucheta,Chattopadhyay, Subrata,Goswami, Dibakar
, p. 490 - 496 (2019/03/07)
A chemoenzymatic synthesis of the title compound has been developed using an efficient and highly enantioselective lipase-catalyzed acylation in a hydrophobic ionic liquid, [bmim][PF6], followed by a diastereoselective asymmetric dihydroxylatio
Organocatalytic route to enantioselective synthesis of ceramide trafficking inhibitor HPA-12
Lalwani, Komal G.,Sudalai, Arumugam
, p. 2445 - 2447 (2016/05/19)
A new organocatalytic approach to the synthesis of ceramide trafficking inhibitor HPA-12 has been described starting from phenacyl bromide. The strategy involves chiral CBS reduction of γ-ketoester and proline-catalyzed α-amination reaction of aldehyde fo
