384793-21-9Relevant articles and documents
Solvent-free, uncatalyzed asymmetric "ene" reactions of: N-Tert-butylsulfinyl-3,3,3-Trifluoroacetaldimines: A general approach to enantiomerically pure α-(trifluoromethyl)tryptamines
Mazzeo, Giuseppe,Longhi, Giovanna,Abbate, Sergio,Palomba, Martina,Bagnoli, Luana,Marini, Francesca,Santi, Claudio,Han, Jianlin,Soloshonok, Vadim A.,Di Crescenzo, Emilio,Ruzziconi, Renzo
, p. 3930 - 3937 (2017/07/11)
A novel approach to regioselectively substituted and stereoselectively α-Trifluoromethylated tryptamines is reported based on the ene reaction of Boc-protected 3-methyleneindolines with optically pure (R)-or (S)-Tert-butanesulfinyltrifluoroacetaldimine. B
Synthesis of new indole-based bisphosphonates and evaluation of their chelating ability in PE/CA-PJ15 cells
Palmerini, Carlo A.,Tartacca, Francesco,Mazzoni, Michela,Granieri, Letizia,Goracci, Laura,Scrascia, Angela,Lepri, Susan
, p. 403 - 412 (2015/09/01)
Bisphosphonates are the most important class of antiresorptive agents used against osteoclast-mediated bone loss, and, more recently, in oncology. These compounds have high affinity for calcium ions (Ca2+) and therefore target bone mineral, whe
COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS
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Page/Page column 171, (2009/10/22)
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is -CR4=CR5.