38677-85-9 Usage
Description
FLUNIXIN MEGLUMINE, also known as Flunixin, is a non-steroidal anti-inflammatory drug (NSAID) derived from pyridinemonocarboxylic acid. It is characterized by its potent non-narcotic, nonsteroidal analgesic properties, along with anti-inflammatory, anti-endotoxic, and anti-pyretic features. Flunixin Meglumine is commonly used in veterinary medicine, particularly in the form of its meglumine salt, for the treatment of horses, cattle, and pigs.
Uses
Used in Veterinary Medicine:
FLUNIXIN MEGLUMINE is used as an anti-inflammatory and analgesic agent for the treatment of various pain and inflammation conditions in horses, cattle, and pigs. It helps in reducing inflammation, pain, and fever, providing relief and comfort to the animals.
Used in Horses:
FLUNIXIN MEGLUMINE is used as an analgesic and anti-inflammatory agent for the management of pain and inflammation associated with musculoskeletal disorders, such as tendonitis, ligament injuries, and joint pain. It also aids in the treatment of post-operative pain and inflammation following orthopedic or soft tissue surgeries.
Used in Cattle:
In cattle, FLUNIXIN MEGLUMINE is used as an anti-inflammatory and analgesic agent for the treatment of pain and inflammation associated with respiratory diseases, such as bovine respiratory disease complex (BRD). It also helps in managing pain and inflammation in cases of mastitis and other inflammatory conditions.
Used in Pigs:
FLUNIXIN MEGLUMINE is used as an analgesic and anti-inflammatory agent in pigs for the management of pain and inflammation associated with various conditions, such as arthritis, lameness, and post-operative pain following surgeries.
Used in Other Applications:
Although not explicitly mentioned in the provided materials, FLUNIXIN MEGLUMINE may also have potential applications in other areas, such as human medicine, where NSAIDs are commonly used for pain relief and inflammation management. However, further research and development would be required to explore these possibilities.
Check Digit Verification of cas no
The CAS Registry Mumber 38677-85-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,6,7 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 38677-85:
(7*3)+(6*8)+(5*6)+(4*7)+(3*7)+(2*8)+(1*5)=169
169 % 10 = 9
So 38677-85-9 is a valid CAS Registry Number.
InChI:InChI=1/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21)
38677-85-9Relevant articles and documents
Polymorphism in the Anti-inflammatory Drug Flunixin and Its Relationship with Clonixin
Camargo, Hernando A.,Contreras, Jines E.,Dávila-Miliani, María Cecilia,Díaz De Delgado, Graciela,Delgado, José Miguel,Dugarte-Dugarte, Analio,Henao, José Antonio,Toro, Robert A.
, p. 4657 - 4666 (2020)
Crystallization of the nonsteroidal anti-inflammatory drug (NSAID) flunixin in acetone and in acetone-hexane produced two conformational polymorphs, as predicted by hydrogen-bond propensity analyses, which are similar to three of the polymorphs of the rel
Preparation method of flunixin meglumine
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Paragraph 0022-0024; 0026-0037; 0042-0045; 0054-0057, (2019/01/24)
The invention discloses a preparation method of flunixin meglumine the preparation method, and the method specifically comprises the following steps: (1) adding 2-chloronicotinic acid and 2-methyl-3-trifluoromethyl aniline into a sodium hydroxide water solution for stirring, adding ethylene glycol as well as a phase transfer catalyst and p-toluenesulfonic acid and copper oxide, controlling the temperature and time, adjusting the pH value of the solution, stirring, standing, layering, stirring, filtering, washing filter cake, and drying to obtain flunixin; and (2) reacting the flunixin obtainedin the step (1) with N-methylglucosamine in isopropyl alcohol, and meanwhile, adding a filler; carrying out heating reflux, filtering, cooling, stirring and crystallizing, carrying out crystal suction filtration, and washing crystals with isopropanol to obtain the flunixin meglumine. The preparation method of the flunixin meglumine is convenient and simple in operation, the reflecting efficiencyis high, the reaction temperature is low, the reaction time is short, and the cost is low; moreover, the prepared flunixin meglumine is high in purity and high in yield.
Process for preparing flunixin and intermediates thereof
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, (2008/06/13)
Process for preparing a key intermediate, 2-methyl-3-trifluoromethylaniline (MTA) of Flunixin, as well as novel intermediates thereof are described.
