387-43-9 Usage
Description
4-Fluoroindole is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical agents and biologically active molecules. It possesses a unique structure with a fluorine atom attached to the indole nucleus, which can modulate the properties and activities of the resulting compounds.
Uses
Used in Pharmaceutical Industry:
4-Fluoroindole is used as a reactant for the preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, which have potential as anticancer immunomodulators. Its unique structure allows for the development of compounds that can target specific enzymes and pathways involved in cancer progression.
4-Fluoroindole is also used as a reactant for the preparation of antifungal agents, contributing to the development of new treatments for fungal infections.
Used in Diabetes Management:
4-Fluoroindole serves as a reactant for the preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) inhibitors, which are used in the management of hyperglycemia in diabetes. These inhibitors help regulate glucose levels by blocking the reabsorption of glucose in the kidneys, leading to improved glycemic control.
Used in Neurotransmitter Regulation:
4-Fluoroindole is used as a reactant for the preparation of potent selective serotonin reuptake inhibitors, which are essential in the treatment of depression and anxiety disorders. These inhibitors work by increasing the availability of serotonin in the synaptic cleft, thereby enhancing neurotransmission and improving mood regulation.
4-Fluoroindole is also used as a reactant for the preparation of monoamine reuptake inhibitors, which target the reuptake of various neurotransmitters, including serotonin, norepinephrine, and dopamine. These inhibitors can be used in the treatment of various psychiatric and neurological disorders.
Used in HIV Treatment:
4-Fluoroindole is used as a reactant for the preparation of inhibitors of HIV-1 attachment, which can help prevent the virus from entering and infecting host cells. This contributes to the development of new therapeutic strategies for HIV treatment and prevention.
Used in Cancer Therapy:
4-Fluoroindole is used as a reactant for the preparation of histone deacetylase (HDAC) inhibitors, which have potential applications in cancer therapy. HDAC inhibitors can modulate gene expression and affect cell cycle regulation, leading to the inhibition of tumor growth and promotion of cell differentiation.
4-Fluoroindole is also used as a reactant for the preparation of inhibitors of proliferation of human breast cancer cells, contributing to the development of targeted therapies for breast cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 387-43-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,8 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 387-43:
(5*3)+(4*8)+(3*7)+(2*4)+(1*3)=79
79 % 10 = 9
So 387-43-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H6FN/c9-7-3-1-2-6-4-5-10-8(6)7/h1-5,10H
387-43-9Relevant articles and documents
Mechanochemical Transformation of CF3 Group: Synthesis of Amides and Schiff Bases
Mkrtchyan, Satenik,Jakubczyk, Micha?,Lanka, Suneel,Yar, Muhammad,Ayub, Khurshid,Shkoor, Mohanad,Pittelkow, Michael,Iaroshenko, Viktor O.
supporting information, p. 5448 - 5460 (2021/10/19)
We communicate two mild, solvent-free mechanochemical coupling transformations of CF3 group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst. This process proceeds via C?F bond activation, accompanied with utilisation of Si-based reductants/oxygen scavengers – reductants of the nitro group. The scope and limitations of the disclosed methodologies are thoroughly studied. To the best of our knowledge, this work is the first example of mechanical energy promoted transformation of the inert CF3 group into other functionalities. (Figure presented.).
A indole compound and its preparation method and application (by machine translation)
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Paragraph 0131; 0134; 0135, (2018/10/02)
The invention discloses a indole compound and its preparation method and application. The indole compounds of the structural formula such as formula (I) is shown. The indoles, rice galenical demonstrate the excellent inhibitory activity, the effect of most of the compound is obviously better than the positive control drug validamycin; especially compound I - 43, I - 44, I - 54, I - 73, II - 7 and II - 17, its galenical very good living body protection and treating effect, effect is better than the positive control; more specifically, compound I - 43 of the rice sheath blight bacteriostatic activity than validamycin activity is improved by nearly 300 times. The indole compounds in the prevention and/or treatment of rice sheath blight has great application prospects. In addition the compound of the invention is simple in construction, the preparation method is simple, and is suitable for large-scale industrial production. (I). (by machine translation)
Alcohol-Enhanced Cu-Mediated Radiofluorination
Zischler, Johannes,Kolks, Niklas,Modemann, Daniel,Neumaier, Bernd,Zlatopolskiy, Boris D.
supporting information, p. 3251 - 3256 (2017/03/17)
The potential of many 18F-labeled (hetero)aromatics for applications in positron emission tomography remains underexplored because convenient procedures for their radiosynthesis are lacking. Consequently, simple methods to prepare radiofluorinated (hetero)arenes are highly sought after. Herein, we report the beneficial effect of primary and secondary alcohols on Cu-mediated 18F-labeling. This observation contradicts the assumption that such alcohols are inappropriate solvents for aromatic fluorination. Therefore, we developed a protocol for rapid radiolabeling of an extraordinarily broad scope of boronic and stannyl substrates under general reaction conditions. Notably, radiofluorinated indoles, phenols, and anilines were synthesized directly from the corresponding unprotected precursors. Furthermore, the novel method enabled the preparation of radiofluorinated tryptophans, [18F]F-DPA, [18F]DAA1106, 6-[18F]FDA, and 6-[18F]FDOPA.
