38767-64-5

Basic information

• Product Name: 3-(naphthalen-1-yl)-1-(naphthalen-2-yl)prop-2-en-1-one
• CAS NO: 38767-64-5
• Molecular Formula: C₂₃H₁₆O
• Molecular Weight: 308.3725
• Mol File: 38767-64-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 525.7°C at 760 mmHg
• Flash Point: 232.8°C
• Density: 1.194g/cm³
• Vapor Pressure: 3.84E-11mmHg at 25°C
• Refractive Index: 1.728
• CAS DataBase Reference: 3-(naphthalen-1-yl)-1-(naphthalen-2-yl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(naphthalen-1-yl)-1-(naphthalen-2-yl)prop-2-en-1-one(38767-64-5)
• EPA Substance Registry System: 3-(naphthalen-1-yl)-1-(naphthalen-2-yl)prop-2-en-1-one(38767-64-5)

Safety Data

• Hazardous Substances Data: 38767-64-5(Hazardous Substances Data)

Upstream product

• 66-77-3 1-naphthaldehyde 
• 93-08-3 methyl 2-naphthyl ketone 
• 75-05-8 acetonitrile 

Relevant articles and documents

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Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death

In this study, we investigated the effects of 24 chalcone derivatives from 2-naphthylacetophenone toward a lymphoblastic leukemia cell line (L1210). Three compounds, called R7, R13, and R15, presented concentration- and time-dependent cytotoxicity and induced cellular death by apoptosis via mitochondrial injury and oxidative stress. The effects of these compounds appear to occur through different mechanisms because R13 and R7 induced a greater disturbance of mitochondrial potential, and all compounds induced disturbances of cellular ATP content and increased caspase-3 activity before cellular death. These compounds also interfered with antioxidant enzymes activities and GSH content through different mechanisms.

Synthesis and biological evaluation of aromatic enones related to curcumin

Curcumin, a natural product isolated from the spice turmeric, has been shown to exhibit a wide range of pharmacological activities including certain anti-cancer properties. It has been specifically shown to be an effective inhibitor of angiogenesis both in vitro and in vivo. Using curcumin as a lead compound for anti-angiogenic analog design, a series of structurally related compounds utilizing a substituted chalcone backbone have been synthesized and tested via an established SVR cell proliferation assay. The results have yielded a wide range of compounds that equal or exceed curcumin's ability to inhibit endothelial cell growth in vitro. Due to both their commercial availability and their fairly straightforward synthetic preparation, these low molecular weight compounds are attractive leads for developing future angiogenic inhibitors.