38881-02-6Relevant articles and documents
Targeting an EGFR Water Network with 4-Anilinoquin(az)oline Inhibitors for Chordoma
Asquith, Christopher R. M.,Maffuid, Kaitlyn A.,Laitinen, Tuomo,Torrice, Chad D.,Tizzard, Graham J.,Crona, Daniel J.,Zuercher, William J.
, p. 1693 - 1700 (2019)
Quinoline- and quinazoline-based kinase inhibitors of the epidermal growth factor receptor (EGFR) have been used to target non-small cell lung cancer (NSCLC) and chordomas with varying amounts of success. We designed and prepared compounds to probe severa