39061-72-8

Basic information

• Product Name: 1-(2-aMino-4-chlorophenyl)ethanone
• Synonyms: 1-(2-aMino-4-chlorophenyl)ethanone;1-(2-Amino-4-chlorophenyl);Ethanone, 1-(2-amino-4-chlorophenyl)-
• CAS NO: 39061-72-8
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.60822
• Mol File: 39061-72-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 310.2°C at 760 mmHg
• Flash Point: 141.4°C
• Appearance: /
• Density: 1.254g/cm³
• Vapor Pressure: 0.000607mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.25±0.10(Predicted)
• CAS DataBase Reference: 1-(2-aMino-4-chlorophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-aMino-4-chlorophenyl)ethanone(39061-72-8)
• EPA Substance Registry System: 1-(2-aMino-4-chlorophenyl)ethanone(39061-72-8)

Safety Data

• Hazardous Substances Data: 39061-72-8(Hazardous Substances Data)

Usage

General Description

1-(2-amino-4-chlorophenyl)ethanone is a chemical compound with the molecular formula C8H8ClNO. It is also known as 4-Amino-3′-chloroacetophenone or Acetophenone, 1-(2-amino-4-chlorophenyl)-. 1-(2-aMino-4-chlorophenyl)ethanone is a pale yellow solid with a molecular weight of 169.61 g/mol. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. 1-(2-amino-4-chlorophenyl)ethanone is also used in research and development activities in the fields of medicine and organic chemistry. It is important to handle this chemical with care, as it can be harmful if ingested, inhaled, or in contact with skin.

InChI:InChI=1/C8H8ClNO/c1-5(11)7-3-2-6(9)4-8(7)10/h2-4H,10H2,1H3

Upstream product

• 197514-04-8 4-chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid 
• 996-82-7 sodium diethylmalonate 
• 23082-51-1 4'-chloro-2'-nitroacetophenone 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 38487-86-4 2-amino-4-chlorobenzonitrile 
• 676-58-4 methylmagnesium chloride 
• 136290-47-6 2-[(tert-butoxycarbonyl)amino]-4-chlorobenzoic acid 
• 1198473-06-1 tert-butyl [5-chloro-2-[methoxy(methyl)carbamoyl]phenyl]carbamate 
• 1204652-83-4 tert-butyl (2-acetyl-5-chlorophenyl)carbamate 
• 917-54-4 methyllithium 
• 635-21-2 5-chloroanthranilic acid 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 675578-62-8 N-(2-acetyl-5-chlorophenyl)-4-methylbenzenesulfonamide 
• 41995-04-4 4-chloro-2-nitro-benzoyl chloride 

Downstream Products

• 18514-94-8 6,7-dichloro-1H-cinnolin-4-one 
• 5465-65-6 4-chloro-3-nitroacetophenone 
• 854888-91-8 7-chloro-4-phenoxy-cinnoline 
• 857560-79-3 1-(2-amino-4-chloro-3-nitro-phenyl)-ethanone 
• 857560-77-1 1-(2-amino-4-chloro-5-nitro-phenyl)-ethanone 
• 96228-48-7 2-acetamido-4-chloro-5-nitroacetophenone 
• 855929-69-0 acetic acid-(6-acetyl-3-chloro-2-nitro-anilide) 
• 2642-63-9 3',4'-dichloroacetophenone 
• 1204652-82-3 7-chloro-1-(2,4-difluorobenzyl)-3-[2-fluoro-3-(trifluoromethyl)phenyl]cinnolin-4(1H)-one 
• 1204652-87-8 3-bromo-7-chloro-1-(2,4-difluorobenzyl)cinnolin-4(1H)-one 
• 1193731-76-8 (S)-6-chloro-3-methylisobenzofuran-1(3H)-one 
• 1363508-25-1 C₉H₈ClNO 
• 1363508-12-6 2-acetyl-5-chlorobenzonitrile 
• 1402345-09-8 4-{(E)-3-[4-chloro-2-(pyridin-2-ylamino)-phenyl]-3-oxo-propenyl}-benzoic acid methyl ester 

Relevant articles and documents

A Convenient Formal [4+2] Heterocylization Route to Bis(triflyl)tetrahydroquinolines

We report the sustainable and efficient synthesis of a new type of quinoline derivatives bearing one or two SO2CF3 groups. The protocol is metal-, catalyst- and irradiation-free, involves the use of readily available and stable precursors, and avoids the formation of side products. Also, the mild conditions of the process allow the tolerance of a wide range of functional groups.

Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks

Described herein is an unusual Cp*CyRh(III)-catalyzed intramolecular site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams with broad substrate/functional group tolerance. Experimental and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.

Synthesis of 3-Sulfonylamino Quinolines from 1-(2-Aminophenyl) Propargyl Alcohols through a Ag(I)-Catalyzed Hydroamination, (2 + 3) Cycloaddition, and an Unusual Strain-Driven Ring Expansion

We describe herein a silver-catalyzed conversion of 1-(2-aminophenyl)-propargyl alcohols to 4-substituted 3-tosylaminoquinolines using TsN3 as an amino surrogate. Controlled reactions reveal the pathway consisting of Ag(I)-catalyzed 5-exo-dig cyclization, catalyst-free (2 + 3) cycloaddition, and ring-expansive rearrangement via nitrogen expulsion. As a support study, we show that the cyclic enamines in similar conditions produce amidines via a C - C bond migration. (Chemical Equation Presented).