39185-03-0

Basic information

• Product Name: 1,3-Propanediol, 2-methylene-, dibenzoate
• CAS NO: 39185-03-0
• Molecular Formula: C18H16O4
• Molecular Weight: 296.323
• Mol File: 39185-03-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Propanediol, 2-methylene-, dibenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanediol, 2-methylene-, dibenzoate(39185-03-0)
• EPA Substance Registry System: 1,3-Propanediol, 2-methylene-, dibenzoate(39185-03-0)

Safety Data

• Hazardous Substances Data: 39185-03-0(Hazardous Substances Data)

Upstream product

• 532-32-1 sodium benzoate 
• 1871-57-4 2-chloromethyl-3-chloroprop-1-ene 
• 79-22-1 methyl chloroformate 
• 57859-50-4 2-(acetoxymethyl)prop-2-en-1-ol 

Downstream Products

• 1005479-20-8 C₂₃H₂₄O₆ 
• 67161-27-7 (Z)-oct-4-ene-1,8-diyl diacetate 
• 705254-60-0 N-6-benzoyl-9-[3-benzoyloxy-2-(benzoyloxymethyl)-2-hydroxypropyl]adenine 
• 705254-59-7 N-4-benzoyl-1-[3-benzoyloxy-2-(benzoyloxymethyl)-2-hydroxypropyl]cytosine 
• 705254-61-1 2-amino-9-[3-benzoyloxy-2-(benzoyloxymethyl)-2-hydroxypropyl]-6-chloropurine 
• 705254-58-6 1-[3-benzoyloxy-2-(benzoyloxymethyl)-2-hydroxypropyl]thymine 
• 873464-94-9 C₃₀H₃₀O₆ 
• 873464-93-8 1,3-dibenzoyl-2-hydroxymethyl-1,2,3-propanetriol 
• 174002-56-3 2,2-bis(benzoyloxymethyl)oxirane 

Relevant articles and documents

Studies on asymmetric synthesis of huperzine A. 1. Palladium-catalyzed asymmetric bicycloannulation of 5,6,7,8-tetrahydro-2-methoxy-6-oxo-5-quinolinecarboxylic esters

A bridged bicyclic compound 8, the key intermediate for the synthesis of huperzine A (1), was prepared by asymmetric palladium-catalyzed bicycloannulation of β-keto ester 2. A variety of chiral ligands and reaction conditions were tested. 52% ee values were observed.

Preparation and antiviral properties of new acyclic, achiral nucleoside analogues: 1- or 9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]nucleobases and 1- or 9-[2,3-dihydroxy-2-(hydroxymethyl)propyl]nucleobases.

Acyclic, achiral nucleoside derivatives 1b-e of adenine, cytosine, 5-methylcytosine, and guanine, containing a 3-hydroxy-2-(hydroxymethyl)prop-1-enyl group on N-1 or N-9, have been prepared analogously to the previously described thymine derivative 1a. In contrast to the adenine and guanine derivatives, the cytosine derivative 9 was unstable, and was obtained in a low yield due to side reactions. These include cleavage of the propenyl group from the base, and the formation of a bicyclic compound. The thymine derivative, although stable under neutral conditions, likewise underwent a reversible cyclization reaction (Michael addition) in the presence of acids or bases. The 5-methylcytosine derivative was stable under neutral and basic conditions. Four other nucleoside derivatives 26a-d containing a 2,3-dihydroxy-2-(hydroxymethyl)propyl group on N-1 or N-9, three of which are new, have likewise been prepared. All compounds were evaluated as antiviral agents against HIV-1 and HSV-1 but were devoid of antiviral activity.