39208-00-9Relevant articles and documents
Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3
Amombo, Ghislaine Marlyse Okala,Kramer, Thomas,Lo Monte, Fabio,Goering, Stefan,Fach, Matthias,Smith, Steven,Kolb, Stephanie,Schubenel, Robert,Baumann, Karlheinz,Schmidt, Boris
, p. 7634 - 7640 (2013/02/21)
The inhibition of FLT-3 activity is an interesting target for the treatment of acute myeloid leukemia (AML). The serendipitous identification of FLT-3 inhibitors from a CK1/γ-secretase programme provided compounds with dual inhibitory activity. We analyzed the structure-activity relationship of these inhibitors and derivatized them to arrive at compounds with reduced impact on γ-secretase activity and enhanced FLT-3 inhibition.
Highly selective and sensitive colorimetric probes for hypochlorite anion based on azo derivatives
Zhang, Dengqing
scheme or table, p. 397 - 401 (2010/11/05)
Two oxime-based colorimetric probes for the hypochlorite anion (ClO -) have been rationally designed and synthesized on basis of the mechanism of intramolecular charge transfer (ICT). Upon addition of ClO -, the probes displayed arou
Modulated conjugation as a means of improving the intrinsic hyperpolarizability
Perez-Moreno, Javier,Zhao, Yuxia,Clays, Koen,Kuzyk, Mark G.,Shen, Yuquan,et al.
body text, p. 5084 - 5093 (2009/09/30)
A new strategy for optimizing the first hyperpolarizability based on theconcept of a modulated conjugated path in linear molecules is investiga ted. A series of seven novel chromophores with different types of conjugated paths were synthesized and characterized. Hyper-Rayleigh scatteringexperiments confirmed that modulated conjugation paths that include ben zene, thiophene, and/or thiazole rings in combination with azo and/or ethenyl linkages between dihydroxyethylamino donor groups and various acceptor groups result in enhanced intrinsic hyperpolarizabilities that exceed the long-standing apparent limit for two of the chromophores. The experimental results are analyzed and interpreted in the context of quantumlimits, which show that conjugation modulation of the bridge in donor/a cceptor molecules simultaneously optimizes the transition moments and the energy-level spacing.