39250-16-3Relevant articles and documents
Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors
Kulikov, Alexander S.,Epishina, Margarita A.,Zhilin, Egor S.,Shuvaev, Alexander D.,Fershtat, Leonid L.,Makhova, Nina N.
, p. 42 - 45 (2021/02/16)
A simple and effective protocol for the synthesis of 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides includes a transformation of accessible 3,4-diacetyl-5-methyl-1H-pyrazoles into the corresponding 1,4-dioximes followed by their N2O4- mediated oxidative cyclization. All transformations proceed under mild conditions in good to high yields. According to the Griess assay, synthesized 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides showed promising NO-donor profiles producing NO in a wide range of concentrations.