40140-16-7

Basic information

• Product Name: ETHYL 4-METHOXYBENZOYLFORMATE
• Synonyms: ETHYL 4-METHOXYBENZOYLFORMATE;ETHYL 2-(4-METHOXYPHENYL)-2-OXOACETATE;(4-METHOXYPHENYL)GLYOXYLIC ACID ETHYL ESTER;ETHYL (4-METHOXYPHENYL)(OXO)ACETATE;Ethyl 2-(4-methoxyphenyl)-2-oxoacetat;4-Methoxy-oxo-benzeneacetic acid ethyl ester
• CAS NO: 40140-16-7
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.21
• Product Categories: Aromatic Esters
• Mol File: 40140-16-7.mol
• Article Data: 64

Chemical Properties

• Boiling Point: 317.566 °C at 760 mmHg
• Flash Point: 139.186 °C
• Appearance: /
• Density: 1.147±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000382mmHg at 25°C
• Refractive Index: 1.5420 (589.3 nm 22℃)
• CAS DataBase Reference: ETHYL 4-METHOXYBENZOYLFORMATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-METHOXYBENZOYLFORMATE(40140-16-7)
• EPA Substance Registry System: ETHYL 4-METHOXYBENZOYLFORMATE(40140-16-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 40140-16-7(Hazardous Substances Data)

Usage

General Description

ETHYL 4-METHOXYBENZOYLFORMATE is a chemical compound with the molecular formula C11H12O4. It is an ester, formed by the condensation of ethyl 4-methoxybenzoate and formic acid. This organic compound is commonly used as a flavoring agent and fragrance in various products including perfumes, soaps, and cosmetics. It is also utilized in the pharmaceutical industry as an intermediate for the synthesis of other organic compounds. ETHYL 4-METHOXYBENZOYLFORMATE is known for its sweet, floral aroma and is considered to be safe for human consumption and use in regulated quantities.

InChI:InChI=1/C11H12O4/c1-3-15-11(13)10(12)8-4-6-9(14-2)7-5-8/h4-7H,3H2,1-2H3

Upstream product

• 7099-91-4 p-methoxybenzoylformic acid 
• 4755-77-5 Ethyl oxalyl chloride 
• 100-66-3 methoxybenzene 
• 95-92-1 oxalic acid diethyl ester 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 64-17-5 ethanol 
• 20714-90-3 4-Methoxymandelic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 75716-82-4 imidazol-1-yl-oxo-acetic acid ethyl ester 
• 14062-18-1 ethyl p-methoxyphenylacetate 
• 161144-23-6 2-Ethoxy-1-(4-methoxy-phenyl)-propenone 
• 6957-89-7 Ethyl dichloro-(ethoxy)-acetate 
• 76344-78-0 ethyl 3-(N,N-dimethylamino)-2-(p-methoxyphenyl)propenoate 
• 70080-54-5 4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester 

Downstream Products

• 15482-31-2 1-hydroxy-1-methyl-1-(4'-methoxyphenyl)-2-propanone 
• 14062-18-1 ethyl p-methoxyphenylacetate 
• 36141-66-9 ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 86871-40-1 dichloro-(4-methoxy-phenyl)-acetic acid ethyl ester 
• 61365-41-1 N-Isopropyl-2-(4-methoxy-phenyl)-2-oxo-acetamide 
• 93809-97-3 Cyclohexyl-<4-methoxy-phenyl>-glykolsaeure-aethylester 
• 78587-65-2 Methyl 3-p-methoxyphenyl-2H-1,4-benzoxazin-2-one-6-acetate 
• 78587-71-0 Methyl 3-p-methoxyphenyl-2H-1,4-benzoxazin-2-one-6-α-methyl-acetate 
• 7099-91-4 p-methoxybenzoylformic acid 
• 198287-28-4 ethyl 2-(4-methoxyphenyl)-2-hydroxypropanoate 
• 190433-55-7 N-benzyl-2-(4-methoxyphenyl)-2-oxoacetamide 
• 135765-83-2 ethyl (E)-2-(hydroxyimino)-2-(4-methoxyphenyl)acetate 
• 250602-54-1 ethyl (Z)-2-(hydroxyimino)-2-(4-methoxyphenyl)acetate 
• 916058-70-3 ethyl (p-methoxyphenyl)-[N-(p-methoxyphenyl)imino]acetate 

Relevant articles and documents

A short route to access oxaspiro[: N,3,3]propellanes

Novel access to oxaspiro[n,3,3]propellanes has been developed from bicyclic lactones directly prepared by a photochemical hydroxymethylation or alternatively by a three-step sequence. Thanks to the presence of additional hydroxy- and propargylic groups, a second cyclization catalyzed by silver or bismuth salts, led to the propellane structure which was finally transformed into spiranic derivatives by a Simmons-Smith reaction or condensation with α-ketoesters.

Electrochemical two-electron oxygen reduction reaction (ORR) induced aerobic oxidation of α-diazoesters

Electrochemical oxygen reduction reaction (ORR) is a powerful tool for introducing oxygen functional groups in synthetic chemistry. However, compared with the well-developed one-electron oxygen reduction process, the applications of two-electron oxygen re

Copper on charcoal: Cu0nanoparticle catalysed aerobic oxidation of α-diazo esters

By using a charcoal supported nano Cu0catalyst (Cu/C), a highly efficient oxidation of α-diazo esters to α-ketoesters with molecular oxygen as the sole oxidant has been developed. In the presence of the Cu/C catalyst, 2-aryl-α-diazo esters with both electron-donating and electron-withdrawing groups can be oxidized to the corresponding α-ketoesters efficiently. Furthermore, this Cu/C catalyst can catalyse the reaction of aryl α-diazo ester with water to form aryl ketoester, 2-aryl-2-hydroxyl acetate ester and 2-aryl acetate ester. In this case, water is split by α-diazo ester, and the diazo group is displaced by the oxygen or hydrogen atom in water. Mechanistic investigation showed that the reaction of α-diazo ester with oxygen proceeds through a radical pathway. In the presence of 2,2,6,6-tetramethyl piperidine nitrogen oxide, the reaction of α-diazo ester with oxygen is dramatically inhibited. Furthermore, the reaction of α-diazo ester with water is investigated by an isotopic tracer method, and GCMS detection showed that a disproportionation reaction occurred between α-diazo ester and water.