40230-94-2

Basic information

• Product Name: Silane, trimethyl[[2-(trifluoromethyl)phenyl]ethynyl]-
• CAS NO: 40230-94-2
• Molecular Formula: C12H13F3Si
• Molecular Weight: 242.316
• Mol File: 40230-94-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Silane, trimethyl[[2-(trifluoromethyl)phenyl]ethynyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, trimethyl[[2-(trifluoromethyl)phenyl]ethynyl]-(40230-94-2)
• EPA Substance Registry System: Silane, trimethyl[[2-(trifluoromethyl)phenyl]ethynyl]-(40230-94-2)

Safety Data

• Hazardous Substances Data: 40230-94-2(Hazardous Substances Data)

Upstream product

• 1066-54-2 trimethylsilylacetylene 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 444-29-1 2-iodo(trifluoromethyl)benzene 

Downstream Products

• 68755-42-0 4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one 
• 262268-63-3 (E)-1-[2-bromovinyl]-2-trifluoromethylbenzene 
• 851227-31-1 {4-[3-isopropyl-4-methoxymethoxy-5-(2-trifluoromethylphenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester 
• 863640-10-2 {4-[4-hydroxy-3-isopropyl-5-(2-trifluoromethyl-phenylethynyl)-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 704-41-6 1-ethynyl-2-(trifluoromethyl)benzene 

Relevant articles and documents

Copper-Catalyzed Ring Opening of [1.1.1]Propellane with Alkynes: Synthesis of Exocyclic Allenic Cyclobutanes

Despite the long history and interesting properties of propellanes, these compounds still have tremendous potential to be exploited in synthetic organic chemistry. Herein we disclose an experimentally simple procedure to achieve cyclobutane-containing allenes and alkynes through a copper-catalyzed ring opening of [1.1.1]propellane and subsequent reaction with ethynes.

Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H- indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management

Vanilloid receptor TRPV1 is a cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective antagonists is under investigation by several pharmaceutical companies in an effort to identify novel agents for pain management. Here we report that replacement of substituted benzyl groups by an indan rigid moiety in a previously described N-indazole-N′-benzyl urea series led to a number of TRPV1 antagonists with significantly increased in vitro potency and enhanced drug-like properties. Extensive evaluation of pharmacological, pharmacokinetic, and toxicological properties of synthesized analogs resulted in identification of (R)-7 (ABT-102). Both the analgesic activity and drug-like properties of (R)-7 support its advancement into clinical pain trials.

ANTIBACTERIAL BENZOIC ACID DERIVATIVES

The invention provides antimicrobial agents and methods of using the agents for sterilization, sanitation, antisepsis, disinfection, and treatment of infections in mammals.