4026-18-0 Usage
Description
2-Hydroxy-3-methylbutyric Acid, also known as a valine derivative, is an α-hydroxylated butyric acid derivative. It is a white solid that has been studied for its chiral resolution without derivatization through capillary electrophoresis using 2-hydroxypropyl-β-cyclodextrin. 2-HYDROXY-3-METHYLBUTYRIC ACID is characterized by the replacement of the amino group in valine with a hydroxy group.
Uses
Used in Medical Diagnostics:
2-Hydroxy-3-methylbutyric Acid is used as a marker in the chemical diagnosis of organic aciduria and other inborn errors. It serves as a metabolomic biomarker in preeclampsia, aiding in the detection and monitoring of these conditions.
Used in Analytical Chemistry:
In the field of analytical chemistry, 2-Hydroxy-3-methylbutyric Acid is employed as an internal standard for the analysis of ethylene glycol (EG) and γ-hydroxybutyrate (GHB) in whole blood. Its use as an internal standard ensures accurate and reliable measurements in these analyses.
Used in Pharmaceutical Research:
The chiral resolution of 2-Hydroxy-3-methylbutyric Acid has been studied for its potential applications in pharmaceutical research. This research could lead to the development of new drugs or the improvement of existing ones, particularly in the treatment of various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 4026-18-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,2 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4026-18:
(6*4)+(5*0)+(4*2)+(3*6)+(2*1)+(1*8)=60
60 % 10 = 0
So 4026-18-0 is a valid CAS Registry Number.
InChI:InChI=1/2C5H10O3.Ca/c2*1-3(2)4(6)5(7)8;/h2*3-4,6H,1-2H3,(H,7,8);/q;;+2/p-2/t2*4-;/m00./s1
4026-18-0Relevant articles and documents
2-Bromo-6-isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry
Van Der Heijden, Gydo,Jong,Ruijter, Eelco,Orru, Romano V. A.
supporting information, p. 984 - 987 (2016/03/15)
The development of 2-isocyanopyridines as novel convertible isocyanides for multicomponent chemistry is reported. Comparison of 12 representatives of this class revealed 2-bromo-6-isocyanopyridine as the optimal reagent in terms of stability and synthetic efficiency. It combines sufficient nucleophilicity with good leaving group capacity of the resulting amide moiety under both basic and acidic conditions. To demonstrate the practical utility of this reagent, an efficient two-step synthesis of the potent opioid carfentanil is presented.
A stable, convertible isonitrile as a formic acid carbanion [ -COOH] equivalent and its application in multicomponent reactions
Kreye, Oliver,Westermann, Bernhard,Wessjohann, Ludger A.
, p. 3188 - 3192 (2008/09/20)
The application of 2-(2,2-dimethoxyethyl) phenyl isonitrile in Ugi, Passerini, and Ugi-Smiles reactions is described. The simple transformation to highly activated indolyl amides allows functional-group conversion of the isonitrile moiety into a variety of carboxylic acid derivatives, overall acting as a neutral, nucleophilic COOH equivalent. Georg Thieme Verlag Stuttgart.
pH-Dependent Chemoselective Synthesis of α-Amino Acids. Reductive Amination of α-Keto Acids with Ammonia Catalyzed by Acid-Stable Iridium Hydride Complexes in Water
Ogo, Seiji,Uehara, Keiji,Abura, Tsutomu,Fukuzumi, Shunichi
, p. 3020 - 3021 (2007/10/03)
An acid-stable hydride complex [Cp*IrIII(bpy)H]+ {1, Cp* = η5-C5Me5, bpy = 2,2′-bipyridine} serves as the active catalyst for the highly chemoselective synthesis of α-amino acids by reductive aminatio
