40274-67-7

Basic information

• Product Name: xanthone-2-carboxylic acid
• Synonyms: xanthone-2-carboxylic acid;9-OXOXANTHENE-2-CARBOXYLIC ACID;9-Oxo-9H-xanthene-2-carboxylic acid;Xanthone-2-carboxylic
• CAS NO: 40274-67-7
• Molecular Formula: C14H8O4
• Molecular Weight: 240.22
• Mol File: 40274-67-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: >300 °C
• Boiling Point: 483.6°C at 760 mmHg
• Flash Point: 192.9°C
• Appearance: /
• Density: 1.445g/cm³
• Vapor Pressure: 3.66E-10mmHg at 25°C
• Refractive Index: 1.675
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.94±0.20(Predicted)
• CAS DataBase Reference: xanthone-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: xanthone-2-carboxylic acid(40274-67-7)
• EPA Substance Registry System: xanthone-2-carboxylic acid(40274-67-7)

Safety Data

• Hazardous Substances Data: 40274-67-7(Hazardous Substances Data)

Usage

General Description

Xanthone-2-carboxylic acid is a chemical compound derived from xanthone, a naturally occurring compound found in plants such as mangosteen and others. It is classified as a carboxylic acid, containing a carboxyl group (–COOH) attached to the second carbon atom in the xanthone molecule. Xanthone-2-carboxylic acid has been studied for its potential pharmacological properties, including anti-inflammatory, antioxidant, and anticancer activities. It has also been investigated for its potential to inhibit the growth of bacteria and fungi. Research into this compound is ongoing, with potential applications in the development of new pharmaceuticals and medicinal products.

InChI:InChI=1/C14H8O4/c15-13-9-3-1-2-4-11(9)18-12-6-5-8(14(16)17)7-10(12)13/h1-7H,(H,16,17)

Upstream product

• 5858-28-6 5-methyl-2-nitrobenzaldehyde 
• 108-95-2 phenol 
• 6280-45-1 2-methyl-9H-xanthen-9-one 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 88-67-5 2-Iodobenzoic acid 
• 108060-50-0 2-(4-Ethylphenoxy)benzoesaeure 
• 123-07-9 4-Ethylphenol 
• 118-91-2 ortho-chlorobenzoic acid 
• 21905-69-1 2-(4-methylphenoxy)-benzoic acid 
• 106-44-5 p-cresol 
• 53063-31-3 4-phenoxy-1,3-benzenedicarboxylic acid dimethyl ester 
• 6939-93-1 4-bromo-isophthalic acid 
• 28730-78-1 4-bromo-1,3-benzenedicarboxylic acid dimethyl ester 
• 40586-47-8 4-phenoxy-1,3-benzenedicarboxylic acid 

Downstream Products

• 74733-76-9 7-(N,N-Dimethylsulfamoyl)-9-oxo-9H-xanthene-2-carboxylic acid 

Relevant articles and documents

Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis

Transthyretin is a tetrameric protein which functions as a transporter of thyroxine and retinol-binding protein. Misfolding and amyloid aggregation of transthyretin are known to cause wild-type and hereditary transthyretin amyloidosis. Stabilization of the transthyretin tetramer by low molecular weight compounds is an efficacious strategy to inhibit the aggregation pathway in the amyloidosis. Here, we investigated the inhibitory activities of anthraquinone and xanthone derivatives against amyloid aggregation, and found that xanthone-2-carboxylic acid with one chlorine or methyl group has strong inhibitory activity comparable with that of diflunisal, which is one of the best known stabilizers of transthyretin. X-ray crystallographic structures of transthyretin in complex with the compounds revealed that the introduction of chlorine, which is buried in a hydrophobic region, is important for the strong inhibitory effect of the stabilizer against amyloidogenesis. An in vitro absorption, distribution, metabolism and elimination (ADME) study and in vivo pharmacokinetic study demonstrated that the compounds have drug-like features, suggesting that they have potential as therapeutic agents to stabilize transthyretin.

Highly efficient and regiospecific photocyclization of 2,2′-diacyl bixanthenylidenes

In contrast to the reversible photochemistry of the 2,2′-substituted bixanthenylidenes (1a-f), the photocyclization of 2,2′-diacyl bixanthenylidenes (1g-j) reveals an irreversible process where the initial cyclic intermediate C(E) can undergo a rapid [1,1

Substituted xanthones as antimycobacterial agents*, part 1: Synthesis and assignment of 1H/13C NMR chemical shifts

A series of substituted xanthones was synthesized in order to prove the hypothesis that electron-withdrawing substituents enhance the antimycobacterial activity of these compounds, which is described by means of a QSAR equation with 13C NMR che