404-50-2

Basic information

• Product Name: N-Benzyl-4-fluoro-N-MethylbenzylaMine, 97%
• Synonyms: N-Benzyl-4-fluoro-N-MethylbenzylaMine, 97%;N-Benzyl-1-(4-fluorophenyl)-N-MethylMethanaMine;benzyl-(4-fluoro-benzyl)-methyl-amine
• CAS NO: 404-50-2
• Molecular Formula: C₁₅H₁₆FN
• Molecular Weight: 229.2926432
• Mol File: 404-50-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Benzyl-4-fluoro-N-MethylbenzylaMine, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-4-fluoro-N-MethylbenzylaMine, 97%(404-50-2)
• EPA Substance Registry System: N-Benzyl-4-fluoro-N-MethylbenzylaMine, 97%(404-50-2)

Safety Data

• Hazardous Substances Data: 404-50-2(Hazardous Substances Data)

Usage

General Description

N-Benzyl-4-fluoro-N-MethylbenzylaMine, 97% is a chemical compound with a high purity level of 97%. It consists of a benzyl group, a 4-fluoro substituent, and a methylbenzylamine group. N-Benzyl-4-fluoro-N-MethylbenzylaMine, 97% is commonly used in organic synthesis and pharmaceutical research, due to its potential as a building block in the creation of various pharmaceutical drugs and other organic compounds. Additionally, it is a versatile chemical that has applications in the development of new materials and biological probes.

Upstream product

• 103-67-3 benzyl-methyl-amine 
• 459-46-1 4-Fluorobenzyl bromide 
• 459-57-4 4-fluorobenzaldehyde 
• 124-38-9 carbon dioxide 
• 100-46-9 benzylamine 
• 67-56-1 methanol 
• 67907-60-2 N-(4-fluorophenylmethylene)-benzylamine 

Downstream Products

• 34065-04-8 N-benzyl-N-methyl cyanamide 
• 100-39-0 benzyl bromide 
• 459-46-1 4-Fluorobenzyl bromide 

Relevant articles and documents

Iron-catalyzed chemoselective hydride transfer reactions

A Diaminocyclopentadienone iron tricarbonyl complex has been applied in chemoselective hydrogen transfer reductions. This bifunctional iron complex demonstrated a broad applicability in mild conditions in various reactions, such as reduction of aldehydes over ketones, reductive alkylation of various functionalized amines with functionalized aldehydes and reduction of α,β-unsaturated ketones into the corresponding saturated ketones. A broad range of functionalized substrates has been isolated in excellent yields with this practical procedure.

Cyclopentadienone iron tricarbonyl complexes-catalyzed hydrogen transfer in water

The development of efficient and low-cost catalytic systems is important for the replacement of robust noble metal complexes. The synthesis and application of a stable, phosphine-free, water-soluble cyclopentadienone iron tricarbonyl complex in the reduction of polarized double bonds in pure water is reported. In the presence of cationic bifunctional iron complexes, a variety of alcohols and amines were prepared in good yields under mild reaction conditions.

Direct Methylation of Amines with Carbon Dioxide and Molecular Hydrogen using Supported Gold Catalysts

The N-methylation of amines with CO2 and H2 is an important step in the synthesis of bioactive compounds and chemical intermediates. The first heterogeneous Au catalyst is reported for this methylation reaction with good to excellent yields. The average turnover frequency (TOF) based on surface Au atoms is 45 h-1, which is the highest TOF value ever reported for the methylation of aniline with CO2 and H2. Furthermore, the catalyst is tolerant toward a variety of amines, which includes aromatic, aliphatic, secondary, and primary amines. Preliminary mechanistic studies suggest that the N-alkyl formamide might be an intermediate in the N-methylation of amine process. Moreover, through a one-pot process, it is possible to convert primary amines, aldehydes, and CO2 into unsymmetrical tertiary amines with H2 as a reductant in the presence of the Au catalyst.