405264-04-2

Basic information

• Product Name: 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride
• Synonyms: 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride
• CAS NO: 405264-04-2
• Molecular Formula: C₇H₃ClF₄O₂S
• Molecular Weight: 262.6091328
• EINECS: 1592732-453-0
• Mol File: 405264-04-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 251℃
• Flash Point: 105℃
• Appearance: /
• Density: 1.603
• CAS DataBase Reference: 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride(405264-04-2)
• EPA Substance Registry System: 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride(405264-04-2)

Safety Data

• Hazardous Substances Data: 405264-04-2(Hazardous Substances Data)

Usage

General Description

2-fluoro-6-(trifluoromethyl)benzene-1-sulfonyl chloride is a chemical compound that is commonly used in organic synthesis and as a reagent in the pharmaceutical industry. It is a sulfonyl chloride derivative, which means it contains a sulfonyl functional group attached to a benzene ring. The presence of the fluoro and trifluoromethyl groups makes this compound very reactive and useful for a variety of chemical reactions, including the formation of new carbon-carbon and carbon-heteroatom bonds. Its high reactivity and versatility make it an important building block for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, it can be used as a protective group for alcohols and amines in organic synthesis.

Upstream product

• 709644-60-0 2-fluoro-6-trifluoromethyl-methylsulfanylbenzene 
• 874814-70-7 2-chloro-6-trifluoromethylbenzenesulfonyl chloride 
• 64248-59-5 1,2-difluoro-3-(trifluoromethyl)benzene 
• 54773-19-2 1,2-dichloro-3-(trifluoromethyl)benzene 
• 1416085-71-6 N-(4-(tert-butyl)-2-(trifluoromethyl)phenyl)acetamide 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 344-62-7 N-[2-(trifluoromethyl)phenyl]acetamide 
• 401-80-9 3-fluoro-trifluoromethylbenzene 
• 104540-42-3 2-bromo-1-fluoro-3-(trifluoromethyl)benzene 

Downstream Products

• 1019217-30-1 methyl 4-(2-{1-benzhydryl-5-chloro-2-[2-({[2-fluoro-6-(trifluoromethyl)phenyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}ethoxy)benzoate 
• 540526-47-4 methyl 4-(3-{1-benzhydryl-5-chloro-2-[2-({[2-fluoro-6-(trifluoromethyl)phenyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoate 

Relevant articles and documents

Preparation method of 2-fluoro-6-trifluoromethylbenzenesulfonylchloride

The invention provides a preparation method of 2-fluoro-6-trifluoromethylbenzenesulfonylchloride. The method comprises the following steps: reacting fluoro-3-benzene and alkali serving as main raw materials in an organic solvent to generate a corresponding salt; reacting the generated salt with sulfuryl fluoride under a certain pressure to generate 2-fluoro-6-trifluoromethanesulphonyl fluoride; reacting filtered and distilled reaction liquid with calcium chloride in a mixed solution; filtering, separating and desolventizing the reaction liquid to obtain liquid-state 2-fluoro-6-trifluoromethylbenzenesulfonylchloride of which the yield is 85 percent or more and the purity is 96 percent or more. The preparation method of the 2-fluoro-6-trifluoromethylbenzenesulfonylchloride provided by the invention has the advantages of no use of highly-toxic or poisonous gas, mild conditions, easiness in controlling, adoption of readily-available raw materials, lower cost, no three waste (waste water, waste solid and waste gas) discharge, and suitability for industrial production.

2-fluoro-6-trifluoromethylbenzenesulfonyl chloride synthesis method

The present invention provides a 2-fluoro-6-trifluoromethylbenzenesulfonyl chloride synthesis method. According to the reaction formula defined in the specification, o-trifluoromethylaniline is used as a raw material, and acylation, alkylation, nitration, dealkylation, reduction, diazotization fluorination, hydrolysis and sulfonylation are performed to synthesize an intermediate 2-fluoro-6-trifluoromethylbenzenesulfonyl chloride. According to the present invention, the target is that the synthesis process is suitable for the industrial production, the starting raw material is easy to obtain, the raw material cost is low, the process operating condition is mild, and the method is suitable for industrial production.

A 6 - substituted -2 - trifluoromethylbenzene sulfonyl chloride method for the preparation of

The invention relates to a preparation method of 6-substituted-2-trifluoromethylbenzenesulfonyl chloride as a key intermediate of sulfonamide or sulfonylurea herbicides. The method comprises the following steps: 6-fluoro-2-trifluoromethylbenzenethioether is formed through fluorine displacement and sulfenyl group substitution of a raw material 2,3-dichlorobenzotrifluoride, chlorine oxidative chloridization or substitution of 6-fluoro-2-trifluoromethylbenzenethioether is carried out, and then chlorine oxidative chloridization of the finally obtained material is carried out to obtain the above product. The method has the advantages of easily available raw materials, simple process, high yield and low cost.