406938-39-4

Basic information

• Product Name: (1R,3R)-1-(1,3-benzodioxol-5-yl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid
• CAS NO: 406938-39-4
• Molecular Weight: 336.347
• Mol File: 406938-39-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 595.6±50.0 °C(Predicted)
• Density: 1.447±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (1R,3R)-1-(1,3-benzodioxol-5-yl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3R)-1-(1,3-benzodioxol-5-yl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid(406938-39-4)
• EPA Substance Registry System: (1R,3R)-1-(1,3-benzodioxol-5-yl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid(406938-39-4)

Safety Data

• Hazardous Substances Data: 406938-39-4(Hazardous Substances Data)

Usage

Description

(1R,3R)-1-(1,3-benzodioxol-5-yl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid, also known as Elzivirine, is a complex carboxylic acid derivative with a unique chemical structure that features a benzodioxol ring and a pyridoindole ring. (1R,3R)-1-(1,3-benzodioxol-5-yl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid holds potential pharmaceutical applications and is of interest for its potential use in antiretroviral therapy.

Uses

Used in Pharmaceutical Industry:
Elzivirine is utilized as an anti-HIV drug, functioning as a non-nucleoside reverse transcriptase inhibitor. Its distinctive structure and pharmacological properties make it a promising candidate for further research and development in the fight against HIV/AIDS. It offers a novel approach to inhibiting the replication of the virus, which could lead to more effective treatment options for patients.

Upstream product

• 120-57-0 piperonal 
• 153-94-6 D-tryptophan 
• 171752-68-4 (1R,3R)-1-benzo[1,3]dioxol-5-yl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester hydrochloride 
• 171596-41-1 (1R,3R)-methyl 1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate 
• 59259-90-4 5-(dimethoxymethyl)benzo[d][1,3]dioxole 

Downstream Products

• 2058231-15-3 (1R,3R)-1-(1,3-benzodioxol-5-yl)-2-(2-methylaminoacetyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid 

Relevant articles and documents

Alternative synthesis of tadalafil: PDE5 inhibitor

Two-step alternative synthesis of tadalafil (1) is described. The synthesis features Pictet-Spengeler type reaction and DCC (N,N′- dicyclohexylcarbodiimide)/HOBt (N-hydroxybenzotriazole)-mediated double amidation employing sarcosine ethyl ester hydrochlor

Method for synthesizing tadalafil

The invention discloses a method for synthesizing tadalafil. Tadalafil is synthesized from D-tryptophan and a compound of formula 1. The method for preparing tadalafil of the invention can effectivelyprepare tadalafil. In addition, the starting material piperonyl dimethyl acetal of the preparation method is easy to obtain as a non-controlled material, the procurement and management are not restricted, the use of the controlled material piperonyl is effectively avoided, the management and procurement are convenient, the process steps are short, the production cost is greatly reduced, and the preparation method is more suitable for large-scale and industrial production of tadalafil.

Chemical compounds

Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.