40823-41-4Relevant articles and documents
STUDIES ON THE CHEMO- AND STEREOSELECTIVITY OF SODIUM BOROHYDRIDE-POLYETHYLENE GLYCOL 400-MEDIATED REDUCTIONS
Santaniello, Enzo,Ferraboschi, Patrizia,Fiecchi, Alberto,Grisenti, Paride,Manzocchi, Ada
, p. 701 - 704 (2007/10/02)
Chemo- and stereoselectivity of reductions by the NaBH4/polyethylene glycol (PEG) 400 system have been studied and compared to the traditional NaBH4 reductions in methanol.When the stereoselectivity was tested on 3- and 7-keto steroids 1a and 1b, respectively, interesting improvements were observed.Aldehydes were reduced faster than ketones and in the case of 3-oxo-pregn-4-en-20β-carboxaldehyde, 2a, the aldehyde was reduced completely leaving the unsatured ketone moiety unchanged.Absorption on inorganic support or addition of a few cationic species led to inactive or much less active reducing species.
Additivity relationships in carbon-13 nuclear magnetic resonance spectra of dihydroxy steroids.
VanAntwerp,Eggert,Meakins,Miners,Djerassi
, p. 789 - 793 (2007/10/07)
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