41051-18-7Relevant articles and documents
Regioselective synthesis of sterically encumbered diaryl ethers based on one-pot cyclizations of 4-aryloxy-1,3-bis(trimethylsilyloxy)-1,3-dienes
Rashid, Muhammad A.,Rasool, Nasir,Adeel, Muhammad,Reinke, Helmut,Spannenberg, Anke,Fischer, Christine,Langer, Peter
, p. 529 - 535 (2008)
Sterically encumbered diaryl ethers are prepared based on formal [3+3] cyclizations of novel 4-aryloxy-1,3-bis(trimethylsilyloxy)-1,3-dienes.
COMPOUNDS AS RAS INHIBITORS AND USE THEREOF
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Paragraph 0219, (2019/04/11)
A compound of Formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.
Phosphine-Mediated Iterative Arene Homologation Using Allenes
Zhang, Kui,Cai, Lingchao,Jiang, Xing,Garcia-Garibay, Miguel A.,Kwon, Ohyun
, p. 11258 - 11261 (2015/09/21)
A PPh3-mediated multicomponent reaction between o-phthalaldehydes, nucleophiles, and monosubstituted allenes furnishes functionalized non-C2-symmetric naphthalenes in synthetically useful yields. When the o-phthalaldehydes were reacted with 1,3-disubstituted allenes in the presence of PPh2Et, naphthalene derivatives were also obtained in up to quantitative yields. The mechanism of the latter transformation is straightforward: aldol addition followed by Wittig olefination and dehydration. The mechanism of the former is a tandem γ-umpolung/aldol/Wittig/dehydration process, as established by preparation of putative reaction intermediates and mass spectrometric analysis. This transformation can be applied iteratively to prepare anthracenes and tetracenes using carboxylic acids as pronucleophiles.