41099-25-6

Basic information

• Product Name: 1H-Inden-1-one, 2,3-bis(4-methoxyphenyl)-
• CAS NO: 41099-25-6
• Molecular Formula: C23H18O3
• Molecular Weight: 342.394
• Mol File: 41099-25-6.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1H-Inden-1-one, 2,3-bis(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Inden-1-one, 2,3-bis(4-methoxyphenyl)-(41099-25-6)
• EPA Substance Registry System: 1H-Inden-1-one, 2,3-bis(4-methoxyphenyl)-(41099-25-6)

Safety Data

• Hazardous Substances Data: 41099-25-6(Hazardous Substances Data)

Upstream product

• 3262-89-3 triphenylboroxine 
• 201230-82-2 carbon monoxide 
• 2132-62-9 4,4'-dimethoxydiphenylacetylene 
• 611-73-4 Benzoylformic acid 
• 93-58-3 benzoic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 20383-28-2 N,N-diisopropyl benzamide 
• 15563-32-3 N,N-diisopropyl-4-thiobenzamide 
• 3376-24-7 N-tert-butyl-α-phenylnitrone 
• 100-52-7 benzaldehyde 
• 5720-07-0 4-methoxyphenylboronic acid 
• 405161-48-0 2,3-dibromoinden-1-one 
• 6630-33-7 ortho-bromobenzaldehyde 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 1195190-00-1 2,3-bis(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one 

Relevant articles and documents

Synthesis of Indenones Via Palladium-Catalyzed Carbonylation with Mo(CO)6 as a CO Surrogate

Transition-metal-catalyzed carbonylation of alkynes has emerged as a powerful engine for the synthesis of indenone compounds. Herein, we reported the development of an effective Pd-catalyzed ligand-free carbonylation of o-bromoaryl iodides with alkynes to afford indenone compounds. A broad range of functional groups on o-bromoaryl iodides and alkynes were tolerated in this protocol, giving carbonylation products. Furthermore, considering the factors of safety and operability, Mo(CO)6 was introduced into the reaction as a carbonyl source. Mechanistic investigations suggested that the reaction proceeded through sequential oxidative addition, alkyne insertion, carbonyl insertion, and reductive elimination steps to produce the observed carbonylation indenone products. Moreover, the indenones obtained with Mo(CO)6 as a CO surrogate can be functionalized to form synthetic useful derivatives via an environmentally friendly way.

Synthesis of Indenones via Palladium-Catalyzed Ligand-Free Carbonylation

A palladium-catalyzed ligand-free carbonylation reaction has been developed for the synthesis of indenones. Under CO atmosphere, this cascade reaction proceeded smoothly to provide the desired indenones in moderate to excellent yields with good functional-group compatibility. The mechanistic investigations suggested the in situ formation of palladium nanoparticles and this transformation was driven by a controlled reaction sequence of alkyne insertion followed by carbonylation and annulation to form the indenone framework. (Figure presented.).

Synthesis method for 2,3-diphenyl-1H-indene-1-one derivatives

The invention discloses a synthesis method for 2,3-diphenyl-1H-indene-1-one derivatives. The synthesis method comprises the steps of: adding benzoyl formic acid, a diphenyl acetylene compound, pentamethyl cyclopentadiene dichloride iridium, copper acetate, silver hexafluoroantimonate and a silver hexafluoroantimonate into an organic solvent; heating for reaction in the presence of air; and after the reaction, carrying out post-treatment to obtain the 2,3-diphenyl-1H-indene-1-one derivative. The method synthesizes the 2,3-diphenyl-1H-indene-1-one derivative in one step through simple and easilyavailable raw materials, so that the conversion efficiency is high and the atomic economical benefit is good. Meanwhile, the synthetic method is simple to operate, high in reaction yield and wide inprimer adaptability.