413597-66-7

Basic information

• Product Name: ethyl 3-(benzyloxy)-1-{[(tert-butyloxy)carbonyl]amino}cyclobutane-1-carboxylate
• Synonyms: ethyl 3-(benzyloxy)-1-{[(tert-butyloxy)carbonyl]amino}cyclobutane-1-carboxylate
• CAS NO: 413597-66-7
• Molecular Weight: 349.427
• Mol File: 413597-66-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: ethyl 3-(benzyloxy)-1-{[(tert-butyloxy)carbonyl]amino}cyclobutane-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(benzyloxy)-1-{[(tert-butyloxy)carbonyl]amino}cyclobutane-1-carboxylate(413597-66-7)
• EPA Substance Registry System: ethyl 3-(benzyloxy)-1-{[(tert-butyloxy)carbonyl]amino}cyclobutane-1-carboxylate(413597-66-7)

Safety Data

• Hazardous Substances Data: 413597-66-7(Hazardous Substances Data)

Upstream product

• 180205-43-0 3-(benzyloxy)-1-carbethoxycyclobutane-1-carboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 1035655-28-7 1-amino-3-(benzyloxy)cyclobutane-1-carboxylic acid ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 64-17-5 ethanol 
• 30830-27-4 3-benzyloxy cyclobutanone 
• 191110-49-3 2-(benzyloxy)-5,7-diazaspiro[3.4]octane-6,8-dione 
• 54166-15-3 diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate 
• 54307-67-4 1-bromo-2-benzyloxy-3-chloropropane 

Downstream Products

• 413597-70-3 1-amino-3-(2-aminoethylthio)-cyclobutane carboxylic acid 
• 140480-88-2 (+/-)-1-amino-3-(phosphonomethylene)cyclobutanecarboxylic acid 
• 216872-94-5 3-(benzyloxy)-1-((tert-butoxycarbonyl)-amino)cyclobutane-1-carboxylic acid 
• 1616599-83-7 N-(3-chloro-2-fluorobenzyl)-2’-ethyl-9’-hydroxy-trans-3-methoxy-1‘,8’-dioxo-1‘,2’,4’,8’-tetrahydrospiro[cyclobutane-1,3’-pyrido[1,2-a]pyrazine]-7’-carboxamide 

Relevant articles and documents

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PURIFICATION OF PRECURSOR COMPOUND BY CRYSTALLISATION

The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1 -amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET tracer.

PREPARATION OF PET PRECURSOR

The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabeled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [18F]-1-amino-3- fluorocyclobutanecarboxylic acid ([18F] FACBC) PET agent and particularly to the work-up process of this precursor removing generated salts from the intermediate composition.