41564-65-2

Basic information

• Product Name: (2E)-1-(4-methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one
• Synonyms: 2-propen-1-one, 1-(4-methoxyphenyl)-3-(4-methylphenyl)-, (2E)-
• CAS NO: 41564-65-2
• Molecular Formula: C₁₇H₁₆O₂
• Molecular Weight: 252.3077
• Mol File: 41564-65-2.mol
• Article Data: 56

Chemical Properties

• Boiling Point: 412.1°C at 760 mmHg
• Flash Point: 183.9°C
• Density: 1.096g/cm³
• Vapor Pressure: 5.3E-07mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: (2E)-1-(4-methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(4-methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one(41564-65-2)
• EPA Substance Registry System: (2E)-1-(4-methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one(41564-65-2)

Safety Data

• Hazardous Substances Data: 41564-65-2(Hazardous Substances Data)

Usage

Description

(2E)-1-(4-methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one is a ketone with a 1-(4-methoxyphenyl)prop-2-en-1-one backbone and a 4-methylphenyl substituent. It is classified as an α, β-unsaturated ketone due to the presence of a C=C double bond in the β-position to the carbonyl group. This chemical compound has potential applications in organic synthesis and pharmaceutical research, as its structural features make it suitable for use as a building block in the synthesis of more complex organic molecules. Additionally, its aromatic substituents make it a valuable starting material for the development of new pharmaceuticals or agrochemicals.

Uses

Used in Organic Synthesis:
(2E)-1-(4-methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one is used as a building block for the synthesis of more complex organic molecules. Its α, β-unsaturated ketone structure allows for various chemical reactions, making it a versatile compound in organic synthesis.
Used in Pharmaceutical Research:
(2E)-1-(4-methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one is used as a starting material for the development of new pharmaceuticals. Its aromatic substituents and unique structure make it a promising candidate for the creation of novel drug molecules.
Used in Agrochemical Development:
(2E)-1-(4-methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one is also used as a starting material for the development of new agrochemicals. Its structural features and potential reactivity make it a valuable compound for the creation of innovative agrochemical products.

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 138711-20-3 1-(4-Methoxy-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethanesulfinyl]-ethanone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 51410-44-7 1-(4-methoxylphenyl)-2-propen-1-ol 
• 5720-05-8 4-methylphenylboronic acid 
• 15851-89-5 (E)-p-methylcinnamoyl chloride 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 7099-91-4 p-methoxybenzoylformic acid 
• 20912-79-2 4-methoxyphenacylidene dimethylsulphurane 
• 40739-81-9 p-tolualdehyde p-toluenesulfonylhydrazone 
• 196862-13-2 2-(1H-1,2,3-benzotriazol-1-yl)-1-<4-(methyloxy)phenyl>-2-(4-methylphenyl)-3-(trimethylsilyl)propan-1-one 
• 589-18-4 4-Methylbenzyl alcohol 
• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 

Downstream Products

• 32383-88-3 (2RS,3SR)-2,3-epoxy-1-(4-methoxyphenyl)-3-(4-methylphenyl)propan-1-one 
• 169803-53-6 4-(4-Methoxy-phenyl)-4-oxo-2-p-tolyl-butyronitrile 
• 106511-65-3 3-(4-methylphenyl)-1-(4’-methoxyphenyl)propan-1-one 
• 1132907-10-8 (2-hydroxy-2-(4-methoxyphenyl)-4,5-di-p-tolylcyclopentyl)(4-methoxyphenyl)methanone 
• 1234670-67-7 3-(4-methoxyphenyl)-3-oxo-1-p-tolylpropyl diethylcarbamodithioate 
• 1260620-88-9 6-(4-methoxyphenyl)-3-methyl-1-phenyl-4-p-tolyl-1H-pyrazolo[3,4-b]pyridine 
• 127394-79-0 2-methoxy-6-(4-methoxy-phenyl)-4-p-tolyl-nicotinonitrile 
• 1548642-17-6 1-(4-methoxyphenyl)-3-(1H-pyrazol-1-yl)-3-p-tolylpropan-1-one 

Relevant articles and documents

Alkene Synthesis by Photo-Wolff-Kischner Reaction of Sulfur Ylides and N-Tosylhydrazones

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Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors

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Synthesis, characterization, molecular docking and in vitro anticancer activity of 3-(4-methoxyphenyl)-5-substituted phenyl-2-pyrazoline-1-carbothioamide

In the present study, eight numbers of new 3-(4-methoxy phenyl)-5-substituted phenyl-2-pyrazoline-1-carbothioamide (5a-h) have been synthesized from 1-(4-methoxy phenyl)-3-(substituted phenyl)-prop-2-en-1-one (3a-h) and structurally characterized by using FT-IR,1H NMR,13C NMR, Mass and Elemental analysis. The synthesized molecules were biologically eval-uated for their in vitro anticancer activity against human breast adenocar-cinoma (MCF-7), liver cancer (Hep-G2) and leukaemia cancer (K-562) cell line using Sulforhodamine B (SRB) bioassay technique. From the all synthesized compounds 5a, 5c, 5d, and 5e exhibited potent anticancer activity (GI50= 50=44.5μg/ml) and Adriamycin (ADR) (GI50= 10μg/ml) on MCF-7 cell lines. Besides this, all the synthesized compounds have exhibited moderate activity against human liver cancer (Hep-G2) and leukaemia cancer (K-562) cell lines. In addition, molecular docking studies were also explored in order to study the probable binding specificity into the active site of Epidermal Growth Factor Receptor tyrosine kinase (EGFR) (PDB ID: 1M17) using Molegro Virtual Docker Evaluation 2013 6.0.1 (MVD). Based on the molecular docking result, it was found that compound 5a exhibited the best interaction with the above target (i.e., EGFR) by interacting with specific amino acid residues such as: Thr 766, Gin 767, Thr 830, Cys 575, Ala 719 and Met 769.