4170-24-5Relevant articles and documents
Preparation method for 2-chloro-butyric acid
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Paragraph 0016-0023, (2019/02/04)
The invention discloses a preparation method for 2-chloro-butyric acid. The preparation method comprises the following steps: taking butyric acid as raw material, chlorine as chlorinating agent, acylating chlorination reagent as catalyst and quinone compound as radical scavenger, and then reacting, thereby acquiring a target product 2-chloro-butyric acid. The preparation method has the advantagesof simple process, high selectivity, high production safety and low cost.
Reaction of Lithium Acylate α-Carbanions with Carbon Tetrachloride
Zorin,Zaynashev,Zorin
, p. 42 - 46 (2019/04/27)
Metalation of acetic, butanoic, or 2-methylpropanoic acid with lithium diisopropylamide in tetrahydrofuran under argon gave the corresponding lithium acylate α-carbanions which reacted with carbon tetrachloride at 20–25°C for 2 h to afford butanedioic acid or its 2,3-diethyl and 2,2,3,3-tetramethyl derivatives, as well as the corresponding α-chlorocarboxylic acids and chloroform. A radical mechanism was proposed for the formation of dicarboxylic and α-chlorocarboxylic acids.
Reactions of α-carbanions of lithium acylates with N,N-diethyl-N-chloro- and N,N-diethyl-N-bromoamines
Zorin,Zainashev,Zorin
, p. 2469 - 2472 (2016/12/24)
The interaction of α-carbanions of lithium acylates (prepared via metalation of acetic, butyric, or isobutyric acid with lithium diisopropylamide in tetrahydrofuran under argon atmosphere) with N,N-diethyl-N-chloro- or N,N-diethyl-N-bromoamine has resulte