41830-97-1

Basic information

• Product Name: Methanone, phenyl[4-(trifluoromethoxy)phenyl]-
• CAS NO: 41830-97-1
• Molecular Formula: C14H9F3O2
• Molecular Weight: 266.219
• Mol File: 41830-97-1.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Methanone, phenyl[4-(trifluoromethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, phenyl[4-(trifluoromethoxy)phenyl]-(41830-97-1)
• EPA Substance Registry System: Methanone, phenyl[4-(trifluoromethoxy)phenyl]-(41830-97-1)

Safety Data

• Hazardous Substances Data: 41830-97-1(Hazardous Substances Data)

Upstream product

• 456-55-3 1-trifluoromethoxybenzene 
• 98-88-4 benzoyl chloride 
• 93-97-0 benzoic acid anhydride 
• 139301-27-2 4-trifluoromethoxyphenylboronic acid 
• 65-85-0 benzoic acid 
• 1137-42-4 4-Hydroxybenzophenone 
• 407-14-7 1-bromo-4-(trifluoromethoxy)benzene 
• 100-52-7 benzaldehyde 
• 119-61-9 benzophenone 
• 2070902-77-9 trifluoromethyl 4-fluorobenzene-1-sulfonate 
• 1137-41-3 (4-aminophenyl)(phenyl)methanone 
• 98-80-6 phenylboronic acid 

Downstream Products

• 41830-98-2 [1-Phenyl-1-(4-trifluoromethoxy-phenyl)-meth-(E)-ylidene]-hydrazine 

Relevant articles and documents

Mechanochemical Solvent-Free Suzuki–Miyaura Cross-Coupling of Amides via Highly Chemoselective N?C Cleavage

Although cross-coupling reactions of amides by selective N?C cleavage are one of the most powerful and burgeoning areas in organic synthesis due to the ubiquity of amide bonds, the development of mechanochemical, solid-state methods remains a major challe

Redox-Neutral TEMPO Catalysis: Direct Radical (Hetero)Aryl C?H Di- and Trifluoromethoxylation

Applications of TEMPO. catalysis for the development of redox-neutral transformations are rare. Reported here is the first TEMPO.-catalyzed, redox-neutral C?H di- and trifluoromethoxylation of (hetero)arenes. The reaction exhibits a broad substrate scope, has high functional-group tolerance, and can be employed for the late-stage functionalization of complex druglike molecules. Kinetic measurements, isolation and resubjection of catalytic intermediates, UV/Vis studies, and DFT calculations support the proposed oxidative TEMPO./TEMPO+ redox catalytic cycle. Mechanistic studies also suggest that Li2CO3 plays an important role in preventing catalyst deactivation. These findings will provide new insights into the design and development of novel reactions through redox-neutral TEMPO. catalysis.

Visible-Light Photoredox-Catalyzed and Copper-Promoted Trifluoromethoxylation of Arenediazonium Tetrafluoroborates

We report the development of photoredox-catalyzed and copper-promoted trifluoromethoxylation of arenediazonium tetrafluoroborates, with trifluoromethyl arylsulfonate (TFMS) as the trifluoromethoxylation reagent. This new method takes advantage of visible-light photoredox catalysis to generate the aryl radical under mild conditions, combined with copper-promoted selective trifluoromethoxylation. The reaction is scalable, tolerates a wide range of functional groups, and proceeds regioselectively under mild reaction conditions. Furthermore, mechanistic studies suggested that a Cs[Cu(OCF3)2] intermediate might be generated during the reaction.