42019-06-7

Basic information

• Product Name: methyl 2-(4-acetylphenoxy)-2-methylpropanoate
• CAS NO: 42019-06-7
• Molecular Formula: C₁₃H₁₆O₄
• Molecular Weight: 236.2637
• Mol File: 42019-06-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 344.5°C at 760 mmHg
• Flash Point: 150.7°C
• Density: 1.101g/cm³
• Vapor Pressure: 6.54E-05mmHg at 25°C
• Refractive Index: 1.501
• CAS DataBase Reference: methyl 2-(4-acetylphenoxy)-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-acetylphenoxy)-2-methylpropanoate(42019-06-7)
• EPA Substance Registry System: methyl 2-(4-acetylphenoxy)-2-methylpropanoate(42019-06-7)

Safety Data

• Hazardous Substances Data: 42019-06-7(Hazardous Substances Data)

Upstream product

• 108-95-2 phenol 
• 75-36-5 acetyl chloride 
• 72278-52-5 methyl 2-methyl-2-phenoxypropionate 
• 22421-97-2 methyl 2-chloroisobutyrate 
• 52179-07-4 2-(p-acetylphenoxy)-2-methylpropionic acid 

Downstream Products

• 81466-36-6 2-(4-hydroxyphenoxy)-2-methylpropionic acid methyl ester 

Relevant articles and documents

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists

Free fatty acid receptor 1 (FFA1) is a new potential drug target for the treatment of type 2 diabetes because of its role in amplifying glucose-stimulated insulin secretion in pancreatic β-cell. In the present studies, we identified phenoxyacetic acid derivative (18b) as a potent FFA1 agonist (EC50 = 62.3 nM) based on the structure of phenylpropanoic acid derivative 4p. Moreover, compound 18b could significantly improve oral glucose tolerance in ICR mice and dose-dependently reduced glucose levels in type 2 diabetic C57BL/6 mice without observation of hypoglycemic side effect. Additionally, compound 18b exhibited acceptable PK profiles. In summary, compound 18b with ideal PK profiles exhibited good activity in vitro and in vivo, and might be a promising drug candidate for the treatment of diabetes mellitus.