425-99-0 Usage
Description
2,2-Difluoromalonamide is an organic compound that features a malonamide backbone with two fluorine atoms attached to the adjacent carbon atoms. This unique structure endows it with specific chemical properties that make it valuable in various applications, particularly in the field of organic synthesis.
Uses
Used in Pharmaceutical Industry:
2,2-Difluoromalonamide is used as a synthetic building block for the creation of fluorine-containing endothiopeptide analogs. These analogs are of significant interest due to their potential applications in the development of new drugs with improved pharmacological properties, such as enhanced bioavailability, metabolic stability, and target selectivity.
Used in Organic Synthesis:
In the field of organic synthesis, 2,2-difluoromalonamide serves as a versatile reagent for the preparation of a wide range of fluorinated compounds. The presence of fluorine atoms in the molecule can significantly influence the reactivity, stability, and biological activity of the resulting products, making it a valuable tool for the synthesis of various organic molecules with potential applications in different industries, such as pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 425-99-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,2 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 425-99:
(5*4)+(4*2)+(3*5)+(2*9)+(1*9)=70
70 % 10 = 0
So 425-99-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H4F2N2O2/c4-3(5,1(6)8)2(7)9/h(H2,6,8)(H2,7,9)
425-99-0Relevant articles and documents
Iwasaki et al.
, p. 201,202 (1970)
NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND USE
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Paragraph 0455, (2019/01/17)
Disclosed are a nitrogenous heterocyclic compound, intermediates, a preparation method, a composition and use thereof. The nitrogenous heterocyclic compound in the present invention is as shown in formula I. The compound has a high inhibitory activity towards ErbB2 tyrosine kinase and a relatively good inhibitory activity towards human breast cancer BT-474 and human gastric cancer cell NCI-N87 which express ErbB2 at a high level, and at the same time has a relatively weak inhibitory activity towards EGFR kinase. Namely, the compound is a highly selective small-molecule inhibitor targeted at ErbB2, and hence it has a high degree of safety, and can effectively enlarge the safety window in the process of taking the drug.
INHIBITORS OF BETA-SECRETASE
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Page/Page column 52, (2011/09/30)
The present invention relates to compounds represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided herein.
