42509-80-8

Basic information

• Product Name: ISAZOPHOS
• Synonyms: miral10g;o-(5-chloro-1-(1-methylethyl)-1h-1,2,4-triazol-3-yl)o,o-diethylphosphorothi;o-(5-chloro-1-(1-methylethyl)-1h-1,2,4-triazol-3-yl)o,o-phosphorothioicaci;o-(5-chloro-1-isopropyl-1h-1,2,4-triazol-3-yl)o,o-diethylphosphorothioate;o-5-chloro-1-isopropyl-1h-1,2,4-triazol-3-ylo,o-diethylphosphorothioate;O,O-DIETHYL-O-[1-ISOPROPYL-5-CHLORO-1,2,4-TRIAZOLYL-[3]]-PHOSPHOROTHIOATE;O-DIETHYL-PHOSPHORTHIOATE;O-5-CHLORO-1-ISOPROPYL-1H-1,2,4-TRIAZOLYL-O
• CAS NO: 42509-80-8
• Molecular Formula: C₉H₁₇ClN₃O₃PS
• Molecular Weight: 313.74
• EINECS: 255-863-8
• Product Categories: H-MAnalytical Standards;IPesticides&Metabolites;Alpha sort;Alphabetic;Nematicides;Pesticides;Pesticides&Metabolites;Analytical Standards
• Mol File: 42509-80-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: <25℃
• Boiling Point: bp0.001 100°; bp760 170°
• Flash Point: 188.1°C
• Appearance: /liquid
• Density: 1.22 g/cm3 (20℃)
• Vapor Pressure: 3.3E-06mmHg at 25°C
• Refractive Index: nD20 1.4867
• Storage Temp.: 0-6°C
• PKA: -1.47±0.10(Predicted)
• Water Solubility: 168 mg l-1 (20 °C)
• BRN: 8145294
• CAS DataBase Reference: ISAZOPHOS(CAS DataBase Reference)
• NIST Chemistry Reference: ISAZOPHOS(42509-80-8)
• EPA Substance Registry System: ISAZOPHOS(42509-80-8)

Safety Data

• Hazard Codes: T+,N
• Statements: 24/25-26-43-48/20-50/53
• Safety Statements: 28-36/37-38-45-59-61
• RIDADR: 3018
• WGK Germany: 3
• RTECS: TE7760000
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 42509-80-8(Hazardous Substances Data)

Usage

Description

ISAZOPHOS is a yellow liquid with a solubility of 168 mg/L in water at 20°C. It is miscible with common organic solvents and has a Log Kow value of 2.99. It undergoes hydrolysis in aqueous media, with DT50 values at pH 5, 7, and 9 being 85, 48, and 19 days, respectively.

Uses

Used in Agriculture:
ISAZOPHOS is used as a nematicide and soil insecticide for the protection of various crops, including bananas, citrus, cotton, beet, maize, rice, vegetables, sugar cane, and turf.
Used in Pest Control:
ISAZOPHOS is used as an organophosphate pesticide to control nematodes and insects in agricultural settings.
Used in Turf Management:
ISAZOPHOS is used as a turf insecticide to protect and maintain the health of turf grasses by controlling pests and nematodes.

Metabolic pathway

Isazofos is metabolised in soil to its hydrolysis product 5-chloro-1- isopropyl-3-triazolol. The oxon metabolite has apparently not been identified.

Metabolism

In mammals, administered isazofos is rapidly metabolized and excreted, primarily in the urine, without accumulation in the body. The degradation route of isazofos in soil is primarily the hydrolysis mediated by microorganisms to give 5-chloro-1-isopropyl-3-triazole. The half-life in soils is about 10 d.

Toxicity evaluation

Acute oral LD50 for rats is 40–60 mg/kg. Inhalation LC50 (4 h) for rats is about 0.24 mg/L air. NOEL (90 d) for rats is 2 mg/kg diet (0.1 mg/kg/d).

Degradation

Isazofos is hydrolysed more rapidly in alkaline rather than acid solution. The DT50 values at pH 5, 7 and 9 were 85, 48 and 19 days, respectively (PM).

InChI:InChI=1/C9H17ClN3O3PS/c1-5-14-17(18,15-6-2)16-9-11-8(10)13(12-9)7(3)4/h7H,5-6H2,1-4H3

Relevant articles and documents

Pesticide compositions and method

Toxicant, especially pesticide compositions, having lowered dermal toxicity are provided. The compositions include a lipophilic-pesticide, a nonionic surfactant and a dry inert diluent carrier. Methods for reducing the dermal toxicity of lipophilic toxicants, especially pesticides are provided, as well as methods for controlling insect pests using the disclosed compositions.