425388-80-3

Basic information

• Product Name: L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine methyl ester
• Synonyms: L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine methyl ester
• CAS NO: 425388-80-3
• Molecular Weight: 389.451
• Mol File: 425388-80-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine methyl ester(425388-80-3)
• EPA Substance Registry System: L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine methyl ester(425388-80-3)

Safety Data

• Hazardous Substances Data: 425388-80-3(Hazardous Substances Data)

Upstream product

• 10439-85-7 N-(benzyloxycarbonyl)-L-prolyl-L-O-tyrosine methyl ester 
• 1192-63-8 1-pyrrolidinecarbonyl chloride 

Relevant articles and documents

DISLODGEMENT AND RELEASE OF HSC USING ALPHA 9 INTEGRIN ANTAGONIST AND CXCR4 ANTAGONIST

Haematopoietic stem cell mobilization is a process whereby haematopoietic stem cells are stimulated out of the bone marrow space. Before HSC can mobilize, they must be dislodged and released from the BM stem cell niche in which they reside and are retained by adhesive interactions. Accordingly, in an aspect of the present invention there is provided a method for enhancing dislodgement of HSC and their precursors and progenitors thereof from a BM stem cell binding ligand in vivo or ex vivo, said method comprising administering in vivo or ex vivo an effective amount of an antagonist of an α9 integrin or an active portion thereof and a CXCR4 antagonist or an active portion thereof to the BM stem cell niche. Once mobilized to the peripheral blood (PB) the HSC may be collected for transplant. Methods which enhance mobilization of the HSC can also improve treatments of haematological disorders.