4276-76-0

Basic information

• Product Name: Benzenemethanol, a-(dichloromethyl)-, acetate
• CAS NO: 4276-76-0
• Molecular Formula: C10H10Cl2O2
• Molecular Weight: 233.094
• Mol File: 4276-76-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-(dichloromethyl)-, acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-(dichloromethyl)-, acetate(4276-76-0)
• EPA Substance Registry System: Benzenemethanol, a-(dichloromethyl)-, acetate(4276-76-0)

Safety Data

• Hazardous Substances Data: 4276-76-0(Hazardous Substances Data)

Usage

Physical State

Colorless liquid

Solvent Usage

Commonly employed as a solvent in various chemical reactions and synthesis processes.

Versatility

Exhibits versatility with potential applications in pharmaceuticals, agrochemicals, and polymer industries.

Reagent in Organic Synthesis

Used as a reagent in organic synthesis.

Intermediate Compound

Serves as a key intermediate in the production of other complex organic compounds.

Hazardous Nature

Requires careful handling due to its hazardous properties.

Health Hazards

Can cause irritation to the skin, eyes, and respiratory system if proper precautions are not taken.

Upstream product

• 90-17-5 2,2,2-trichloro-1-phenylethyl acetate 
• 140-10-3 (E)-3-phenylacrylic acid 
• 64-19-7 acetic acid 
• 4110-77-4 (E)-β-chlorostyrene 

Relevant articles and documents

Efficient partial hydrogenation of trichloromethyl to gem-dichloromethyl groups in platinum on carbon-catalyzed system

While gem-dichloromethyl groups can be directly synthesized by the mono-dechlorination of the corresponding trichloromethyl groups, the suppression control of the over-reduction to form chloromethyl or methyl functionalities is quite difficult. We have established the efficient and widely applicable mono-dechlorination method of the trichloromethyl groups to form the corresponding gem-dichloromethyl groups using platinum on carbon in dimethylacetamide as a specific solvent at 25 °C under a hydrogen atmosphere. The mono-dechlorination of the α,α,α- trichloromethylcarbonyl groups smoothly proceeded by the use of platinum on carbon as a catalyst in a highly chemoselective manner, while the efficient mono-dechlorination of the alkyl- and aryl-trichloromethyl groups required the combined use of Bu3SnH.

Reaction of α,β-Unsaturated Carboxylic Acids with Manganese(III) Acetate in the Presence of Chloride Ion

The reaction of 3-phenylpropenoic acids with manganese(III) acetate - Cl- complex yielded 1,2,2-trichloro-1-phenylethanes, 1-acetoxy-2,2-dichloro-1-phenylethanes, and 2,2-dichloro-1-phenylethanols. (E)-2,3-Diphenylpropenoic acids gave 2,2-dichloro-1,2-diphenylethanones and 2-acetoxy-1,2-diphenylethanones. 3,3-Diphenylpropenoic acids yielded 2,2-dichloro-1,1-diphenylethenes, 1-acetoxy-2,2-dichloro-1,1-diphenylethanes, 2,2-dichloro-1,1-diphenyl-1-ethanols, and 2-hydroxy-2,2-diphenylethanal.Fluorenylideneacetic acid gave 9-chloro-9-(dichloromethyl)fluorene, 9-acetoxy-9-(dichloromethyl)fluorene, and 9-fluorenone. 1-Cyclohexenecarboxylic acid yielded 1,2-dichlorocyclohexanecarboxylic acid and 1-acetoxy-2-chlorocyclohexanecarboxylic acid.The reaction can be explained in terms of a free-radical mechanism involving manganese(III) acetate - Cl- complexation, addition of Cl. radical, decarboxylation, and the oxidation of chloroethenes which are the reaction intermediates.