427888-21-9

Basic information

• Product Name: (2S)-1-N-benzyl-2-isopropyl-piperazine-3,6-dione
• Synonyms: (2S)-1-N-benzyl-2-isopropyl-piperazine-3,6-dione
• CAS NO: 427888-21-9
• Molecular Weight: 246.309
• Mol File: 427888-21-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S)-1-N-benzyl-2-isopropyl-piperazine-3,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1-N-benzyl-2-isopropyl-piperazine-3,6-dione(427888-21-9)
• EPA Substance Registry System: (2S)-1-N-benzyl-2-isopropyl-piperazine-3,6-dione(427888-21-9)

Safety Data

• Hazardous Substances Data: 427888-21-9(Hazardous Substances Data)

Upstream product

• 57463-16-8 ethyl (S)-N-benzylvalinate 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 433735-02-5 (S)-N-benzyl-N-chloroacetylvaline methyl ester 
• 4070-48-8 L-Valine methyl ester 
• 100-39-0 benzyl bromide 
• 40216-62-4 N-benzyl-L-valine methyl ester 

Downstream Products

• 427888-18-4 (3S)-1-(2-azidobenzoyl)-4-benzyl-3-isopropylpiperazine-2,5-dione 
• 433735-03-6 (6S)-1-benzyl-5-ethoxy-3,6-dihydro-6-isopropylpyrazine-2-one 
• 427888-23-1 (1S)-2-benzyl-1-isopropyl-1,3,4,6-tetrahydro-2H-pyrazino[2,1-b]quinazoline-3,6-dione 
• 433735-04-7 1-[(3'R,6'S)-1'-benzyl-5'-ethoxy-3',6'-dihydro-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane 
• 433735-12-7 1-[(3'R,6'S)-1'-benzyl-3'-chloromethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane 
• 433735-10-5 1-[(3'R,6'S)-3'-allyl-1'-benzyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane 
• 433735-11-6 1-[(3'R,6'S)-1'-benzyl-3'-benzyloxycarbonylmethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane 

Relevant articles and documents

Reactivity as glycine templates of 1,2-dialkyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-diones

The 1-methyl(iso-propyl)-2-benzyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3, 6-diones 8 and 9 could be regio- and diastereoselectively alkylated at C(4) with retention of configuration at both stereocentres.