43188-65-4

Basic information

• Product Name: methyl (2S,3S)-3-methyl-1-[(4-methylphenyl)sulfonyl]aziridne-2-carboxylate
• Synonyms: methyl (2S,3S)-3-methyl-1-[(4-methylphenyl)sulfonyl]aziridne-2-carboxylate
• CAS NO: 43188-65-4
• Molecular Weight: 269.321
• Mol File: 43188-65-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: methyl (2S,3S)-3-methyl-1-[(4-methylphenyl)sulfonyl]aziridne-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S,3S)-3-methyl-1-[(4-methylphenyl)sulfonyl]aziridne-2-carboxylate(43188-65-4)
• EPA Substance Registry System: methyl (2S,3S)-3-methyl-1-[(4-methylphenyl)sulfonyl]aziridne-2-carboxylate(43188-65-4)

Safety Data

• Hazardous Substances Data: 43188-65-4(Hazardous Substances Data)

Upstream product

• 72-19-5 L-threonine 
• 98-59-9 p-toluenesulfonyl chloride 
• 83860-98-4 (2S,3S)-H-3-MeAzy-OMe 
• 74481-55-3 methyl (2S,3R)-3-hydroxy-2-triphenylmethylaminobutanoate 
• 74481-56-4 methyl (2S,3S)-N-triphenylmethyl-3-methylaziridine-2-carboxylate 
• 39994-75-7 L-threonine methyl ester hydrochloride 
• 43188-53-0 (2S,3R)-methyl-N-(4-methylphenylsulfonyl)-3-hydroxy-2-aminobutanoate 

Downstream Products

• 910041-07-5 methyl (2S,3S)-2-(para-toluenesulfonylamino)-3-methylpent-4-ynoate 
• 17360-25-7 N-(p-toluenesulfonyl)-L-valine 
• 95305-52-5 (2S,3S) methyl 3-methyl-2-(4-methylphenylsulfonamido)pentanoate 
• 161529-11-9 (2S,3S)-2-(para-toluenesulfonylamino)-3-methylpent-4-ynoic acid 
• 161529-09-5 (2S,3S)-2-(para-toluenesulfonylamino)-3-methyl-5-trimethylsilylpent-4-ynoic acid 
• 1026878-39-6 (2S,5S,3E)-2-methyl-5-hex-3-en-1-yl benzyl ether 
• 169686-74-2 N-((E)-(1S,4R)-5-Hydroxy-1,4-dimethyl-pent-2-enyl)-4-methyl-benzenesulfonamide 
• 190961-94-5 (2S,5S)-(E)-5-[N-(p-toluenesulfonyl)amino]-2-methylhex-3-enol 
• 209266-15-9 (S)-N-benzyl-2-(p-tolylsulfonyl-amino)propanol 
• 158195-28-9 (E)-(2R,5S)-2-Methyl-5-(toluene-4-sulfonylamino)-hex-3-enoic acid methyl ester 
• 158195-23-4 (E)-(2S,5S)-2-Methyl-5-(toluene-4-sulfonylamino)-hex-3-enoic acid methyl ester 

Relevant articles and documents

Asymmetric Synthesis of β2-Aryl Amino Acids through Pd-Catalyzed Enantiospecific and Regioselective Ring-Opening Suzuki–Miyaura Arylation of Aziridine-2-carboxylates

A Pd-catalyzed enantiospecific and regioselective ring-opening Suzuki–Miyaura arylation of aziridine-2-carboxylates was developed. The cross-coupling allows for the asymmetric preparation of enantioenriched β2-aryl amino acids, starting from co

New methodology for the preparation of N-tosyl aziridine-2-carboxylates

N-Tosyl aziridine-2-carboxylate methyl esters were prepared from methyl N-tosyl-l-serinate or N-tosyl-l-threoninate, tosyl chloride, and K2CO3, under phase-transfer catalysis (PTC) conditions. The same methodology, as applied to the

Reduction of 2-acylaziridines by samarium(II) iodide. An efficient and regioselective route to β-amino carbonyl compounds

A convenient method for the reduction of 2-acylaziridines, aziridine-2- carboxylates and aziridine-2-carboxamides is described. The reduction of all of the substrates examined was extremely rapid and highly regioselective, giving rise to β-amino carbonyl compounds. This method appears to be general for all of the classes of aziridines mentioned above, and also tolerates a variety of nitrogen protecting groups.