433-14-7

Basic information

• Product Name: 4-Fluoro-N-methylbenzenesulphonamide
• Synonyms: 4-Fluoro-N-methylbenzenesulphonamide;4-fluoro-N-methylbenzenesulfonamide;N-Methyl 4-fluorobenzenesulfonamide;BenzenesulfonaMide, 4-fluoro-N-Methyl-
• CAS NO: 433-14-7
• Molecular Formula: C₇H₈FNO₂S
• Molecular Weight: 189.2073232
• Mol File: 433-14-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 56-58
• Boiling Point: 278.8°Cat760mmHg
• Flash Point: 122.4°C
• Appearance: /
• Density: 1.311g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.34±0.30(Predicted)
• CAS DataBase Reference: 4-Fluoro-N-methylbenzenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-N-methylbenzenesulphonamide(433-14-7)
• EPA Substance Registry System: 4-Fluoro-N-methylbenzenesulphonamide(433-14-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 433-14-7(Hazardous Substances Data)

Usage

General Description

4-Fluoro-N-methylbenzenesulphonamide, also known as 4-FPSA, is a chemical compound with the molecular formula C7H8FNO2S. It is a sulfonamide derivative with a fluoro substitution at the 4-position of the benzene ring and a methyl group attached to the nitrogen atom. 4-Fluoro-N-methylbenzenesulphonamide is commonly used in pharmaceutical research and drug development, particularly as a building block for the synthesis of potential antitumor and antimicrobial agents. It is also utilized in organic synthesis and medicinal chemistry due to its diverse reactivity and potential pharmacological activities. 4-FPSA has shown promise as an inhibitor of certain enzymes and is being investigated for its potential therapeutic applications.

Upstream product

• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 402-46-0 4-fluorophenylsulphonamide 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 593-51-1 methylamine hydrochloride 
• 67-56-1 methanol 
• 824-75-9 p-fluorobenzamide 
• 74-89-5 methylamine 

Downstream Products

• 1620220-76-9 C₁₁H₁₂FNO₃S 
• 1608477-76-4 N-(8-chloroquinolin-3-yl)-4-fluoro-N-methylbenzenesulfonamide 
• 1352570-76-3 tert-butyl 4-fluorophenylsulfonyl(methyl)carbamate 

Relevant articles and documents

Copper-catalyzed oxidative methylation of sulfonamides by dicumyl peroxide

A novel and facile copper-catalyzed methylation of sulfonamides was herein demonstrated. The practical transformation took place readily under the oxidative conditions, and N-methyl amides (23 examples) were successfully furnished in high efficiency (up to 90% yields). Dicumyl peroxide was considered to act not only as the oxidant in the system, but also methyl donor for the methylation protocol.

Recyclable covalent triazine framework-supported iridium catalyst for the N-methylation of amines with methanol in the presence of carbonate

An iridium complex Cp*Ir@CTF, which is synthesized by the coordinative immobilization of [Cp*IrCl2]2 on a functionalized covalent triazine framework (CTF), was found to be a general and highly efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate. Under environmentally benign conditions, a variety of desirable products were obtained in high yields with complete selectivities and functional group friendliness. Furthermore, the synthesized catalyst could be recycled by simple filtration without obvious loss of catalytic activity after sixth cycle. Notably, this research exhibited the potential of covalent triazine framework-supported transition metal catalysts for hydrogen autotransfer process.

Method for synthesizing N-methyl sulfonamide in water

The invention discloses a method N - for synthesizing,methylsulfamide in water, by using a transition metal iridium catalyst to catalyze N - methylation reaction. by using a non-toxic and harmless water as a solvent, to avoid using the organic agent; to react only as a byproduct, without an environmental hazard; reaction temperature with respect to the previous strip more mild; and have a wide application prospect; with high selectivity, reaction atomic economy.