434-02-6

Basic information

• Product Name: (11beta)-21-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione
• Synonyms: 21-FLUORO-11B,17-DIHYDROXYPREGN-4-ENE-3,20-DIONE; Progesterone, 21-fluoro-11.beta.,17-dihydroxy-
• CAS NO: 434-02-6
• Molecular Formula: C₂₁H₂₉FO₄
• Molecular Weight: 364.451
• Mol File: 434-02-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 538°C at 760 mmHg
• Flash Point: 279.2°C
• Density: 1.26g/cm³
• Vapor Pressure: 8.1E-14mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: (11beta)-21-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (11beta)-21-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione(434-02-6)
• EPA Substance Registry System: (11beta)-21-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione(434-02-6)

Safety Data

• Hazardous Substances Data: 434-02-6(Hazardous Substances Data)

Usage

Description

(11beta)-21-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione is a synthetic corticosteroid that belongs to the class of glucocorticoids. It is a derivative of the natural hormone cortisol, with an added fluorine atom at the 21st position. This chemical has anti-inflammatory and immunosuppressant properties, and it is commonly used in the treatment of various inflammatory and autoimmune conditions such as rheumatoid arthritis, asthma, and dermatitis. Its mechanism of action involves binding to glucocorticoid receptors and modulating gene expression, leading to a reduction in inflammation and immune response. Additionally, it has mineralocorticoid activity, meaning it can affect electrolyte balance and fluid regulation in the body.

Uses

Used in Pharmaceutical Industry:
(11beta)-21-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione is used as an anti-inflammatory and immunosuppressant drug for the treatment of various inflammatory and autoimmune conditions such as rheumatoid arthritis, asthma, and dermatitis. Its anti-inflammatory and immunosuppressant properties make it effective in managing these conditions by reducing inflammation and immune response.
Used in Medical Treatment:
(11beta)-21-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione is used as a medication to treat patients suffering from inflammatory and autoimmune conditions. Its mechanism of action, which involves binding to glucocorticoid receptors and modulating gene expression, helps in reducing inflammation and immune response, providing relief to the patients.
Used in Electrolyte Balance and Fluid Regulation:
(11beta)-21-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione is used as a mineralocorticoid to affect electrolyte balance and fluid regulation in the body. Its ability to modulate these processes can be beneficial in managing conditions related to electrolyte imbalances and fluid retention.

Upstream product

• 33767-06-5 11β,17α-dihydroxy-21-iodopregn-4-ene-3,20-dione 
• 6677-96-9 11β,7α-dihydroxy-21-<(methylsulfonyl)oxy>pregn-4-ene-3,20-dione