4342-43-2

Basic information

• Product Name: 2-Methoxy-cyclohexylaMine
• Synonyms: 2-Methoxy-cyclohexylaMine;2-MethoxycyclohexanaMine
• CAS NO: 4342-43-2
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2001
• Mol File: 4342-43-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-Methoxy-cyclohexylaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-cyclohexylaMine(4342-43-2)
• EPA Substance Registry System: 2-Methoxy-cyclohexylaMine(4342-43-2)

Safety Data

• Hazardous Substances Data: 4342-43-2(Hazardous Substances Data)

Usage

General Description

2-Methoxy-cyclohexylamine is a chemical compound that consists of a cyclohexyl ring with a methoxy substituent and an amine functional group. It is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals. 2-Methoxy-cyclohexylaMine has been studied for its potential use in the treatment of various medical conditions, including epilepsy and depression. It is also known for its potential neuroprotective properties and has been investigated for its potential role in the treatment of neurodegenerative diseases. 2-Methoxy-cyclohexylamine is considered to have low toxicity and is not known to be a significant environmental pollutant.

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 91-23-6 2-Nitroanisole 
• 6850-38-0 2-aminocyclohexanol 
• 7429-44-9 2-methoxycyclohexanone 
• 93-26-5 2-methoxyacetanilide 

Downstream Products

• 1424464-11-8 1-(3-fluoro-4-hydroxy-benzyl)-3-(2-methoxy-cyclohexyl)-urea 

Relevant articles and documents

Highly efficient one-pot multi-directional selective hydrogenation and N-alkylation catalyzed by Ru/LDH under mild conditions

Atomic economy, non-toxicity, harmlessness and multidirectional selectivity advocated by green chemistry have increasingly become a hot and difficult research topic. Herein, we present a highly efficient, one-pot tandem and easy-to-operate method through which we could directly produce a broad range of multi-directional selective hydrogenated amines or N-alkyl aliphatic amines using aromatic nitro compounds as raw materials. Ru/LDH with characteristics of layered mesoporous structure, well dispersed small Ru nanoparticles and LDH stabilization to the Ru NPs was employed as the catalyst. It is remarkable that multi-directional superb chemoselectivity to aromatic amines, alicyclic amines as well as N-alkyl aliphatic amines could be achieved with excellent catalytic activity and recyclability by tuning reaction conditions over 5wt%Ru/LDH-2. Additionally, this catalytic system also exhibited attractive activity and multi-directional chemoselectivity in the hydrogenation of quinoline and its derivatives with solvents of different polarity. Chemoselectivity to 5,6,7,8-tetrahydroquinoline derivatives could reach as high as 95.6 %.

Asymmetric Reductive Amination of Ketones Catalyzed by Imine Reductases

Biocatalysis employing imine reductases is a promising approach for the one-step generation of chiral amines from ketones. The enzymes reported for this process suffer from low activity and moderate stereoselectivity. We identified a set of enzymes that facilitate this reaction with high to quantitative conversions from a library of 28 imine reductases. This enabled the conversion of ketones with ammonia, methylamine, or butylamine into the corresponding amines. Most importantly, we performed preparative (>100 mg) scale syntheses of amines such as (1S,3R)-N,3-dimethylcyclohexylamine and (R)-N-methyl-2-aminohexane with excellent stereochemical purities (98 % de, 96 % ee) in good yields.