436-32-8 Usage
Description
DIFFRACTIC ACID is a lichen metabolite derived from P. magellanica, exhibiting a range of biological activities, including cytotoxicity against various cancer cell lines, inhibition of M. tuberculosis growth, and analgesic properties.
Used in Pharmaceutical Industry:
DIFFRACTIC ACID is used as a cytotoxic agent for its ability to inhibit the growth of HCT116, HeLa, and MCF-7 cancer cells, making it a potential candidate for cancer treatment.
Used in Antimicrobial Applications:
DIFFRACTIC ACID is used as an antimicrobial agent for its growth-inhibiting effects on M. tuberculosis, suggesting its potential use in treating tuberculosis.
Used in Anti-inflammatory Applications:
DIFFRACTIC ACID is used as an anti-inflammatory agent for its ability to reduce neutrophil infiltration, lipid peroxidation, myeloperoxidase (MPx) activity, and the number of gastric lesions, as well as for its capacity to reverse decreases in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities induced by indomethacin in rat gastric mucosa.
Used in Analgesic Applications:
DIFFRACTIC ACID is used as an analgesic agent for its effectiveness in reducing acetic acid-induced writhing and increasing the pressure pain threshold in mice, indicating its potential use in pain management.
Check Digit Verification of cas no
The CAS Registry Mumber 436-32-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,3 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 436-32:
(5*4)+(4*3)+(3*6)+(2*3)+(1*2)=58
58 % 10 = 8
So 436-32-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H22O7/c1-9-8-14(11(3)17(21)15(9)19(22)23)27-20(24)16-10(2)7-13(25-5)12(4)18(16)26-6/h7-8,21H,1-6H3,(H,22,23)
436-32-8Relevant articles and documents
Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth. 1. Novel analogues of barbatic and diffractaic acid
Kumar, Sunil,Mueller, Klaus
, p. 1035 - 1042 (2007/10/03)
A series of barbatic and diffractaic acid analogues has been synthesized and evaluated as inhibitors of leukotriene B4 (LTB4) biosynthesis and as antiproliferative agents. The 4-O-demethyl barbatic and diffractaic acid derivatives were among the most active compounds in both assays. In particular, ethyl 4-O-demethylbarbatate was the most potent LTB4 biosynthesis inhibitor of this series, with an IC50 value in the submicromolar range. Because the compounds did not show appreciable reactivity against a stable free radical, 2,2-diphenyl-1-picrylhydrazyl, and did not produce appreciable amounts of deoxyribose degradation as a measure of their potency to generate hydroxyl radicals, a simple redox effect could not explain their biological activity. Also, there was no nonspecific cytotoxicity as documented by the activity of lactate dehydrogenase released from the cytoplasm of keratinocytes, which was in the control range.