4366-35-2

Basic information

• Product Name: 4',7-dimethoxyisoflavan
• Synonyms: 4',7-dimethoxyisoflavan
• CAS NO: 4366-35-2
• Molecular Weight: 270.328
• Mol File: 4366-35-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4',7-dimethoxyisoflavan(CAS DataBase Reference)
• NIST Chemistry Reference: 4',7-dimethoxyisoflavan(4366-35-2)
• EPA Substance Registry System: 4',7-dimethoxyisoflavan(4366-35-2)

Safety Data

• Hazardous Substances Data: 4366-35-2(Hazardous Substances Data)

Upstream product

• 1157-39-7 7-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 186581-53-3 diazomethane 
• 531-95-3 equol 
• 15236-11-0 4',7-dimethoxyisoflavanone 
• 213970-41-3 3-(2-hydroxy-4-methoxyphenyl)-2-(4-methoxyphenyl)-1-propanol 
• 64-19-7 acetic acid 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 124555-63-1 4-methoxy-2-methoxymethoxy benzaldehyde 
• 126809-68-5 2-(methoxymethoxy)-4-methoxybenzyl alcohol 
• 152955-15-2 4-methoxy-2-O-methoxymethylbenzyl bromide 
• 213970-36-6 2-(4-methoxyphenyl)-3-(4-methoxy-2-O-methoxymethylphenyl)-1-propanol 
• 213970-29-7 methyl 2-(4-methoxyphenyl)-3-(4-methoxy-2-O-methoxymethylphenyl)propanoate 
• 1029608-23-8 C₁₈H₂₀O₄ 

Downstream Products

• 15236-11-0 4',7-dimethoxyisoflavanone 

Relevant articles and documents

Synthesis, structure-activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors

In a continuing study for discovering urease inhibitors based on flavonoids, nineteen reductive derivatives of flavonoids were synthesized and evaluated against Helicobacter pylori urease. Analysis of structure-activity relationship disclosed that 4-deoxy analogues are more potent than other reductive products. Out of them, 4′,7,8-trihydroxyl-2-isoflavene (13) was found to be the most active with IC50 of 0.85 μM, being over 20-fold more potent than the commercial available urease inhibitor, acetohydroxamic acid (AHA). Kinetics study revealed that 13 is a competitive inhibitor of H. pylori urease with a Ki value of 0.641 μM, which is well matched with the results of molecular docking. Biological evaluation and mechanism study of 13 suggest that it is a good candidate for discovering novel anti-gastritis and anti-gastric ulcer agent.

The direct synthesis of isoflavans VIA α-alkylation of phenylacetates

Deprotonation of oxygenated phenylacetates and quenching of the enolates with oxygenated benzylic electrophiles, afforded 2,3-diarylpropanoates which served as precursors to the isoflavans following consecutive reduction and cyclization steps.