4406-41-1

Basic information

• Product Name: 2-METHYL-N-PHENYL-PROPANAMIDE
• Synonyms: 2-METHYL-N-PHENYL-PROPANAMIDE;2-Methyl-N-phenylpropionamide;N-Phenyl-2-methylpropanamide;N-Phenyl-2-methylpropionamide;N-Phenylisobutyramide;PropanaMide, 2-Methyl-N-phenyl-
• CAS NO: 4406-41-1
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.2163
• Mol File: 4406-41-1.mol
• Article Data: 86

Chemical Properties

• Boiling Point: 317.8°Cat760mmHg
• Flash Point: 185.8°C
• Appearance: /
• Density: 1.046g/cm³
• Vapor Pressure: 0.000375mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 2-METHYL-N-PHENYL-PROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-N-PHENYL-PROPANAMIDE(4406-41-1)
• EPA Substance Registry System: 2-METHYL-N-PHENYL-PROPANAMIDE(4406-41-1)

Safety Data

• Hazardous Substances Data: 4406-41-1(Hazardous Substances Data)

Usage

General Description

2-Methyl-N-phenyl-propanamide is a chemical compound used in the production of pharmaceuticals and other organic substances. It is a white to off-white crystalline solid with a molecular formula of C11H15NO. 2-METHYL-N-PHENYL-PROPANAMIDE is classified as an amide, which is a derivative of a carboxylic acid. Its primary use is as an intermediate in the synthesis of various pharmaceuticals, such as anti-inflammatory and analgesic drugs. Additionally, it can also be utilized as a precursor in the production of other organic compounds, such as dyes and pigments. However, it is important to handle and store this chemical with care, as it may present risks to human health and the environment if not properly managed.

InChI:InChI=1/C10H13NO/c1-8(2)10(12)11-9-6-4-3-5-7-9/h3-8H,1-2H3,(H,11,12)

Upstream product

• 1068-55-9 isopropylmagnesium chloride 
• 103-71-9 phenyl isocyanate 
• 920-39-8 isopropylmagnesium bromide 
• 933-52-8 2,2,4,4-tetramethyl-1,3-cyclobutanedione 
• 60-29-7 diethyl ether 
• 62-53-3 aniline 
• 598-26-5 dimethylketene 
• 563-83-7 ISOPROPYLAMIDE 
• 14088-58-5 3-diazo-2-butanone 
• 2322-45-4 2-bromo-2-methyl-N-phenylpropanamide 
• 68-12-2 N,N-dimethyl-formamide 
• 72846-71-0 (Z)-2-methyl-1-phenylpropan-1-one oxime 
• 39241-02-6 N-(3-bromophenyl)-2-methylpropanamide 
• 64-19-7 acetic acid 

Downstream Products

• 4834-64-4 N,N'-diphenyl-isobutyramidine 
• 50993-22-1 α-chloro-N-phenyl-isobutyrimidoyl chloride 
• 114841-20-2 N-(4-sulfamoylphenyl)isobutyramide 
• 1309448-76-7 N-(2-(4-chlorobenzoyl)phenyl)isobutyramide 
• 17840-96-9 2-isobutyramidobenzoic acid 
• 588-47-6 N-isobutylaniline 
• 69737-54-8 N,N-diphenyl-2-methylpropanamide 
• 17261-12-0 N-([1,1'-biphenyl]-2-yl)isobutyramide 
• 6316-52-5 2-methyl-N-(2-nitrophenyl)propanamide 
• 1451075-03-8 N-isobutyryl-2-methyl-1H-indole 
• 1315609-21-2 4-(4-isobutyramidophenyl)-3-methyl-4-oxobutyric acid 
• 1266533-97-4 4-(4-isobutyramidophenyl)-4-oxobutyric acid 
• 1266533-91-8 6-(4-isobutyramidophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one 
• 1266533-88-3 2-(4,5-dihydro-1H-imidazol-2-yl)-6-(4-isobutyramidophenyl)-4,5-dihydropyridazin-3(2H)-one 

Relevant articles and documents

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Visible-light induced one-pot hydrogenation and amidation of nitroaromatics with carboxylic acids over 2D MXene-derived Pt/N-TiO2/Ti3C2

Pt nanoparticles supported on N doped titanium dioxide/titanium carbide (MXene) heterojunctions were employed as photocatalysts for the tandem reactions between aromatic nitro compounds and carboxylic acids to produce amide products. The 3%Pt/N-TiO2/Ti3C2 heterojunction was prepared by in situ grew TiO2 on Ti3C2 nanosheets and then N doped TiO2 with melamine, Pt nanoparticles with 3.3 nm mean diameter well dispersed on N-TiO2/Ti3C2. 3%Pt/N-TiO2/Ti3C2 had excellent amidation activity and chemoselectivity under visible-light irradiation. The elevated catalytic performance of 3%Pt/N-TiO2/Ti3C2 was owing to the improvement in photogenerated electron and hole separation efficiency through charge short-range directional transmission caused by the intimate contact between the TiO2 and the conductive Ti3C2. This direct hydrogenation along with amidation between nitroaromatics and carboxylic acids own actual merits in the amides produce with no harmful byproducts. In situ DRIFTS spectra verified that the amidation activation with visible light irradiation at 25 °C was much faster than heating.

Efficient nitriding reagent and application thereof

The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.

Preparation method of amide

The invention relates to a preparation method of an amide, wherein, under the action of oxygen, the isothiocyanate and the aldehyde can react to form an amide, and the reaction temperature can be effectively increased only when not less than 110 °C. This process is also suitable for the reaction of isocyanates with aldehydes to produce amides. The preparation method is cheap in raw material, wide in substrate application range and free of metal catalysts in the reaction process. The initiator or other activator is green and economical, and can effectively reduce the cost.