443-87-8

Basic information

• Product Name: 3-Fluoro-2-methylphenol
• Synonyms: 3-FLUORO-2-METHYLPHENOL;3-Fluoro-2-Methyl Phenol 2-Methyl-3-Fluoro Phenol;2-Methyl-3-fluorophenol;3-Fluoro-2-methylphenol98%;3-Fluoro-2-methylphe;2-Fluoro-6-hydroxytoluene;2-Fluoro-6-hydroxytoluene, 3-Fluoro-o-cresol;Phenol,3-fluoro-2-Methyl-
• CAS NO: 443-87-8
• Molecular Formula: C₇H₇FO
• Molecular Weight: 126.13
• Product Categories: Fluorobenzene;Phenol&Thiophenol&Mercaptan;Benzenes
• Mol File: 443-87-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 53.2-53.9
• Boiling Point: 188°C
• Flash Point: 78°C
• Appearance: /
• Density: 1.164
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.32±0.10(Predicted)
• CAS DataBase Reference: 3-Fluoro-2-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-2-methylphenol(443-87-8)
• EPA Substance Registry System: 3-Fluoro-2-methylphenol(443-87-8)

Safety Data

• Hazard Codes: Xi,T,Xn
• Statements: 22-37/38-41-51
• Safety Statements: 26-39
• HazardClass: TOXIC
• Hazardous Substances Data: 443-87-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

Uses

is used in perparation of indole-like derivatives with ROR-gamma-t regulating activity for prevention and treatment of ROR-gamma-t-related diseases.

Upstream product

• 443-84-5 2,6-difluorotoluene 
• 769-10-8 1-fluoro-2-methyl-3-nitrobenzene 
• 443-86-7 3-fluoro-2-methylaniline 

Downstream Products

• 1221161-09-6 C₁₉H₂₂FN₃O₃ 

Relevant articles and documents

Method for synthesizing 3 - halogen -2 -alkyl phenol

The invention discloses a synthesis method of 3 -halo -2 - alkyl phenol, and belongs to the technical field of organic synthesis. At 2, 6 - dihaloalkylbenzene is used as starting material, nucleophilic substitution with dibenzyl alcohol in the presence of an inorganic base followed Pd / C hydrodebenzylation or Grignard exchange with magnesium metal in the presence of n-butylbromide/chloride followed by air/oxygen to give 3 - halo -2 - alkylphenols. The method has the advantages of high regioselectivity, good yield, simple operation process and the like, and the product purity can reach 99.5% or more.

MONOAMINE RE-UPTAKE INHIBITORS AND METHODS RELATING THERETO

Monoamine re-uptake inhibitors and more specifically serotonin and noradrenaline re-uptake inhibitors are disclosed that have utility in the treatment of disorders of the central or peripheral nervous system in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3, R4, R5, R6, m, n, W, X, Y, and Z are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts, esters and solvates thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting monoamine re-uptake in a subject in need thereof.