4450-39-9Relevant articles and documents
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Baumgarten,H.E. et al.
, p. 3668 - 3673 (1971)
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Microwave-assisted aqueous Krapcho decarboxylation
Mason, Jeremy D.,Murphree, S. Shaun
supporting information, p. 1391 - 1394 (2013/07/26)
The Krapcho decarboxylation of alkyl malonate derivatives has been adapted to aqueous microwave conditions. Various salt additives were examined, and both the cation and the anion impacted the facility of the reaction. A strong correlation was found between the pKa of the anion and the reaction rate, suggesting a straightforward base-catalyzed hydrolysis. Lithium sulfate gave the best results, obviating the need for DMSO co-solvent. Georg Thieme Verlag Stuttgart · New York.
Cleavage of β-ketoesters via iminyl radicals - Application in the synthesis of a spirolactone
Sridar,Babu
, p. 323 - 330 (2007/10/03)
Reaction of Oximebenzoates of several β-ketoesters with tributyltin hydride show β-cleavage via an iminyl radical and application of this results in the synthesis of a spirolactone.