446-32-2

Basic information

• Product Name: 2-Amino-4-fluorobenzoic acid
• Synonyms: TIMTEC-BB SBB006590;BUTTPARK 15\04-96;2-AMINO-4-FLUOROBENZOIC ACID;4-FLUOROANTHRANILIC ACID;2-Amino-4-FluorobenzoicAcid99%;2-Amino-4-Fluorobenzoic Acid 99%;2-Amino-4-fluorobenzoic;2-Amino-4-fluorobenzoicacid97%
• CAS NO: 446-32-2
• Molecular Formula: C₇H₆FNO₂
• Molecular Weight: 155.13
• EINECS: 207-163-9
• Product Categories: Fluorin-contained Benzoic acid series;Amines and Anilines;Amino Acids and Derivatives;Carboxylic Acids;Phenyls & Phenyl-Het;Benzoic acid;Chemical Amines;Amines;Aromatics;Carboxylic Acids;Phenyls & Phenyl-Het;Benzoic acid series;Fluorine series
• Mol File: 446-32-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 192-196 °C(lit.)
• Boiling Point: 223.67°C (rough estimate)
• Flash Point: 146.2 °C
• Appearance: white to light yellow crystal powder
• Density: 1.3021 (estimate)
• Vapor Pressure: 0.331mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 4.88±0.10(Predicted)
• BRN: 2803665
• CAS DataBase Reference: 2-Amino-4-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-fluorobenzoic acid(446-32-2)
• EPA Substance Registry System: 2-Amino-4-fluorobenzoic acid(446-32-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 446-32-2(Hazardous Substances Data)

Usage

Description

2-Amino-4-fluorobenzoic acid is an organic compound characterized by its white to light yellow crystal powder appearance. It is known for its unique chemical properties, which make it a valuable component in various applications across different industries.

Uses

Used in Organic Synthesis:
2-Amino-4-fluorobenzoic acid is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and functional groups allow it to participate in a range of chemical reactions, making it a versatile building block for the creation of new molecules with potential applications in pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Amino-4-fluorobenzoic acid is utilized as a starting material for the development of new drugs. Its specific properties enable it to be incorporated into the molecular structures of potential therapeutic agents, targeting a variety of medical conditions.
Used in Agrochemical Industry:
2-Amino-4-fluorobenzoic acid also finds application in the agrochemical industry, where it is used as a precursor for the synthesis of various pesticides and other crop protection agents. Its unique chemical properties allow for the development of novel compounds with improved efficacy and selectivity.
Used in Research and Development:
In the field of research and development, 2-Amino-4-fluorobenzoic acid serves as an important compound for studying various chemical reactions and mechanisms. Its unique structure and properties make it an ideal candidate for exploring new reaction pathways and understanding the underlying chemistry involved.

InChI:InChI=1/C6H3F2NO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H

Upstream product

• 394-01-4 4-fluoro-2-nitrobenzoic acid 
• 366-49-4 5’-fluoro-2’-methylacetanilide 
• 60-00-4 ethylenediaminetetraacetic acid 
• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 1863-63-4 ammonium benzoate 
• 459-56-3 4-fluorobenzylic alcohol 
• 2475-81-2 methyl 4-fluoroanthranilate 
• 119-32-4 4-Methyl-3-nitroanilin 
• 350-78-7 (2E)-N-(3-fluorophenyl)-2-hydroxyiminoacetamide 
• 367-29-3 3-fluoro-6-methylaniline 
• 446-10-6 2-nitro-4-fluorotoluene 
• 106754-80-7 4-fluoro-2-nitrobenzamide 
• 80517-21-1 4-fluoro-2-nitrobenzonitrile 
• 448-39-5 N-(4-fluoro-2-nitrophenyl)acetamide 

Downstream Products

• 16499-57-3 7-fluoro-3,4-dihydroquinazolin-4-one 
• 117324-05-7 2-amino-4-fluoro-benzoic acid ethyl ester 
• 642491-84-7 6-fluoro-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one 
• 97954-38-6 methyl 4-fluoro-2-(N-methylamino)benzoate 
• 81223-46-3 4-fluoro-2-mercaptobenzyl alcohol 
• 81223-47-4 2-(5-chloro-2-thienylthio)-4-fluorobenzyl alcohol 
• 81223-48-5 2-(5-chloro-2-thienylthio)-4-fluorobenzyl chloride 
• 81223-49-6 <2-(5-chloro-2-thienylthio)-4-fluorophenyl>acetonitrile 
• 81223-45-2 2-(5-chloro-2-thienylthio)-4-fluorobenzoic acid 
• 81223-50-9 <2-(5-chloro-2-thienylthio)-4-fluorophenyl>acetic acid 
• 81223-42-9 dimethyl 2,2'-dithiobis(4-fluorobenzoate) 
• 76088-98-7 7-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 
• 231278-08-3 2-amino-4-fluoro-5-iodo-benzoic acid 
• 862274-39-3 6-fluoro-1H-indazol-3-ol 

Relevant articles and documents

Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease

Based on a multitarget strategy, a series of novel tacrine-pyrimidone hybrids were identified for the potential treatment of Alzheimer's disease (AD). Biological evaluation results demonstrated that these hybrids exhibited significant inhibitory activities toward acetylcholinesterase (AChE) and glycogen synthase kinase 3 (GSK-3). The optimal compound 27g possessed excellent dual AChE/GSK-3 inhibition both in terms of potency and equilibrium (AChE: IC50 = 51.1 nM; GSK-3β: IC50 = 89.3 nM) and displayed significant amelioration on cognitive deficits in scopolamine-induced amnesia mice and efficient reduction against phosphorylation of tau protein on Ser-199 and Ser-396 sites in glyceraldehyde (GA)-stimulated differentiated SH-SY5Y cells. Furthermore, compound 27g exhibited eligible pharmacokinetic properties, good kinase selectivity, and moderate neuroprotection against GA-induced reduction in cell viability and neurite damage in SH-SY5Y-derived neurons. The multifunctional profiles of compound 27g suggest that it deserves further investigation as a promising lead for the prospective treatment of AD.

Selenium-catalyzed intramolecular atom- And redox-economical transformation ofo-nitrotoluenes into anthranilic acids

Anthranilic acids (AAs) are significant basic chemicals used in pharmaceuticals, agrochemicals, dyes, fragrances,etc. Superfluous steps are always involved in obtaining AAs. Herein, we demonstrate a straightforward strategy to transform abundanto-nitrotoluenes into biologically and pharmaceutically significant AAs without any extra reductants, oxidants and protecting groups. Various sensitive groups, such as halogens, sulfide, aldehyde, pyridines, quinolines,etc., can be tolerated in this transformation. A hundred-gram-scale operation is realized efficiently with almost quantitative selenium recycling. Further mechanistic studies and DFT calculations disclosed the proposed atom-exchange processes and the key roles of the selenium species.

ARYLQUINAZOLINES

The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation.