446-58-2 Usage
General Description
2-Fluoro-6-(hydroxymethyl)phenol is a chemical compound that consists of a phenol ring substituted with a fluorine atom and a hydroxymethyl group at the 2 and 6 positions, respectively. It is commonly used in the synthesis of pharmaceuticals and as a building block in the production of various compounds. 2-Fluoro-6-(hydroxymethyl)phenol has been studied for its potential biological activities, including its antifungal and antimicrobial properties. It is also used as a reagent in chemical reactions and as an intermediate in organic synthesis. Overall, 2-Fluoro-6-(hydroxymethyl)phenol has diverse applications in the chemical and pharmaceutical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 446-58-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,4 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 446-58:
(5*4)+(4*4)+(3*6)+(2*5)+(1*8)=72
72 % 10 = 2
So 446-58-2 is a valid CAS Registry Number.
446-58-2Relevant articles and documents
Water-promoted ortho-selective monohydroxymethylation of phenols in the NaBO2 system
Li, Hui-Jing,Wu, Ying-Ying,Wu, Qin-Xi,Wang, Rui,Dai, Chun-Yang,Shen, Zhi-Lun,Xie, Cheng-Long,Wu, Yan-Chao
, p. 3100 - 3107 (2014/05/06)
Water-promoted ortho-selective monohydroxymethylation of phenols in the NaBO2 system generates salicyl alcohols in 65-97% yields. A remarkable rate-enhancement by water was observed, and NaBO2 appeared to serve the dual role of a suitable base and an efficient chelating reagent. This protocol possesses many advantages such as short reaction times, expanded substrate scope, and high mono- and regio-selectivities. The experimental results were explained by the calculations based on local ionisation energy minima, leading to a possible reaction mechanism.
